Browsing Pathology, Department of by Issue Date
Now showing items 1-20 of 20
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Ileal mucosal bile acid absorption is increased in Cftr knockout mice
(2001-10-15)Background: Excessive loss of bile acids in stool has been reported in patients with cystic fibrosis. Some data suggest that a defect in mucosal bile acid transport may be the mechanism of bile acid malabsorption in these ... -
Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo
(2004)The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of direct innate immune ... -
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions
(2004-09-01)Diabetes in humans accelerates cardiovascular disease caused by atherosclerosis. The relative contributions of hyperglycemia and dyslipidemia to atherosclerosis in patients with diabetes are not clear, largely because there ... -
Prehn, R. On the nature of cancer and why anticancer vaccines don't work
(2005)In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The ... -
The role of mutation in the new cancer paradigm
(2005)The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes. In my own ... -
Application of affymetrix array and massively parallel signature sequencing for identification of genes involved in prostate cancer progression
(2005)Background: Affymetrix GeneChip Array and Massively Parallel Signature Sequencing (MPSS) are two high throughput methodologies used to profile transcriptomes. Each method has certain strengths and weaknesses; however, no ... -
Transcriptomes of human prostate cells
(2006)Background: The gene expression profiles of most human tissues have been studied by determining the transcriptome of whole tissue homogenates. Due to the solid composition of tissues it is difficult to study the transcriptomes ... -
Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV
(2006)Background: Jaagsiekte sheep retrovirus (JSRV) causes a lethal lung cancer in sheep and goats. Expression of the JSRV envelope (Env) protein in mouse lung, by using a replication-defective adeno-associated virus type 6 ... -
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
(2006)Background: Inheritance of the three different alleles of the human apolipoprotein (apo) E gene (APOE) are associated with varying risk or clinical outcome from a variety of neurologic diseases. ApoE isoform-specific ... -
An immune reaction may be necessary for cancer development
(2006)Background: The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years. ... -
The paradoxical effects of splenectomy on tumor growth
(2006)Background: There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, ... -
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
(2007)Background: Many studies have shown that mitochondrial dysfunction, complex I inhibition in particular, is involved in the pathogenesis of Parkinson's disease (PD). Rotenone, a specific inhibitor of mitochondrial complex ... -
Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
(2007)Tumor progression: In many (perhaps in all) tumor systems, a malignant cancer is preceded by a benign lesion. Most benign lesions do not transform to malignancy and many regress. The final transformative step to malignancy ... -
Immunostimulation and Immunoinhibition of Premalignant Lesions
(2007)Background: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. Hypothesis: A tumor-stimulatory immune response may be essential ... -
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated a-synuclein
(2007)Background: The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute ... -
Differential expression of CD10 in prostate cancer and its clinical implication
(2007)Background: CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors. Loss of CD10 expression is a common, early event in human prostate cancer; however, CD10 positive ... -
The urologic epithelial stem cell database (UESC) - a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
(2007)Background: Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database http://scgap.systemsbiology.net/ is a public database that ... -
Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
(2008)Background: The diagnosis of invasive pulmonary aspergillosis (IPA) remains challenging. Culture and histopathological examination of bronchoalveolar lavage (BAL) fluid are useful but have suboptimal sensitivity and in the ... -
Correlation of mRNA and protein levels: Cell type-specific gene expression of cluster designation antigens in the prostate
(2008)Background: Expression levels of mRNA and protein by cell types exhibit a range of correlations for different genes. In this study, we compared levels of mRNA abundance for several cluster designation (CD) genes determined ... -
Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity
(2010-04-21)Background: Innate immune activation, including a role for cluster of differentiation 14/toll-like receptor 4 coreceptors (CD14/TLR-4) co-receptors, has been implicated in paracrine damage to neurons in several neurodegenerative ...