Department of Laboratory Medicine and Pathology Faculty Papers and Data
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Dataset: Assessing the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda: a longitudinal cohort study
(University of Washington, 2023-11-07)This is the dataset accompanying Hergott et al. publications related to this field study conducted in Katakwi District, Uganda in March-May 2021. This dataset contains line listings of sample-by-sample data for Plasmodium ... -
Study Protocol: Feasibility of daily dried blood spot sampling to evaluate the natural history of low-density Plasmodium infections
(University of Washington, 2020-03-05)This document is the IRB-approved clinical trial protocol for a field study conducted in 2021 in Uganda. The findings of this study have been published (PMID: 35836179 and additional manuscripts in review). -
High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector
(2008-03-20)Retroviral vector–mediated HSC gene therapy has been used to treat individuals with a number of life-threatening diseases. However, some patients with SCID-X1 developed retroviral vector–mediated leukemia after treatment. ... -
Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging
(2007)Background: 18F-FLT is a novel PET radiotracer which has demonstrated a strong potential utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory approval of 18F-FLT for clinical ... -
The urologic epithelial stem cell database (UESC) - a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
(2007)Background: Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database http://scgap.systemsbiology.net/ is a public database that ... -
Differential expression of CD10 in prostate cancer and its clinical implication
(2007)Background: CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors. Loss of CD10 expression is a common, early event in human prostate cancer; however, CD10 positive ... -
Correlation of mRNA and protein levels: Cell type-specific gene expression of cluster designation antigens in the prostate
(2008)Background: Expression levels of mRNA and protein by cell types exhibit a range of correlations for different genes. In this study, we compared levels of mRNA abundance for several cluster designation (CD) genes determined ... -
Transcriptomes of human prostate cells
(2006)Background: The gene expression profiles of most human tissues have been studied by determining the transcriptome of whole tissue homogenates. Due to the solid composition of tissues it is difficult to study the transcriptomes ... -
Application of affymetrix array and massively parallel signature sequencing for identification of genes involved in prostate cancer progression
(2005)Background: Affymetrix GeneChip Array and Massively Parallel Signature Sequencing (MPSS) are two high throughput methodologies used to profile transcriptomes. Each method has certain strengths and weaknesses; however, no ... -
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated a-synuclein
(2007)Background: The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute ... -
Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
(2007)Tumor progression: In many (perhaps in all) tumor systems, a malignant cancer is preceded by a benign lesion. Most benign lesions do not transform to malignancy and many regress. The final transformative step to malignancy ... -
Immunostimulation and Immunoinhibition of Premalignant Lesions
(2007)Background: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. Hypothesis: A tumor-stimulatory immune response may be essential ... -
The paradoxical effects of splenectomy on tumor growth
(2006)Background: There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, ... -
An immune reaction may be necessary for cancer development
(2006)Background: The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years. ... -
Prehn, R. On the nature of cancer and why anticancer vaccines don't work
(2005)In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The ... -
The role of mutation in the new cancer paradigm
(2005)The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes. In my own ... -
Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection
(2006)Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its ... -
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
(2007)Background: Many studies have shown that mitochondrial dysfunction, complex I inhibition in particular, is involved in the pathogenesis of Parkinson's disease (PD). Rotenone, a specific inhibitor of mitochondrial complex ... -
Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells
(2006)Introduction: Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires ... -
Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
(2005)Background: Commercially available assays to detect antibodies to the herpes simplex virus type 2 (HSV-2)-specific glycoprotein gG-2 have markedly improved serologic diagnosis of HSV-2 infection. However, even tests with ...