Browsing Department of Laboratory Medicine and Pathology Faculty Papers and Data by Title
Now showing items 12-27 of 27
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High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector
(2008-03-20)Retroviral vector–mediated HSC gene therapy has been used to treat individuals with a number of life-threatening diseases. However, some patients with SCID-X1 developed retroviral vector–mediated leukemia after treatment. ... -
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
(2007)Background: Many studies have shown that mitochondrial dysfunction, complex I inhibition in particular, is involved in the pathogenesis of Parkinson's disease (PD). Rotenone, a specific inhibitor of mitochondrial complex ... -
Ileal mucosal bile acid absorption is increased in Cftr knockout mice
(2001-10-15)Background: Excessive loss of bile acids in stool has been reported in patients with cystic fibrosis. Some data suggest that a defect in mucosal bile acid transport may be the mechanism of bile acid malabsorption in these ... -
An immune reaction may be necessary for cancer development
(2006)Background: The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years. ... -
Immunostimulation and Immunoinhibition of Premalignant Lesions
(2007)Background: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. Hypothesis: A tumor-stimulatory immune response may be essential ... -
Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV
(2006)Background: Jaagsiekte sheep retrovirus (JSRV) causes a lethal lung cancer in sheep and goats. Expression of the JSRV envelope (Env) protein in mouse lung, by using a replication-defective adeno-associated virus type 6 ... -
Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo
(2004)The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of direct innate immune ... -
The paradoxical effects of splenectomy on tumor growth
(2006)Background: There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, ... -
Prehn, R. On the nature of cancer and why anticancer vaccines don't work
(2005)In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The ... -
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated a-synuclein
(2007)Background: The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute ... -
The role of mutation in the new cancer paradigm
(2005)The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes. In my own ... -
Study Protocol: Feasibility of daily dried blood spot sampling to evaluate the natural history of low-density Plasmodium infections
(University of Washington, 2020-03-05)This document is the IRB-approved clinical trial protocol for a field study conducted in 2021 in Uganda. The findings of this study have been published (PMID: 35836179 and additional manuscripts in review). -
Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging
(2007)Background: 18F-FLT is a novel PET radiotracer which has demonstrated a strong potential utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory approval of 18F-FLT for clinical ... -
Transcriptomes of human prostate cells
(2006)Background: The gene expression profiles of most human tissues have been studied by determining the transcriptome of whole tissue homogenates. Due to the solid composition of tissues it is difficult to study the transcriptomes ... -
The urologic epithelial stem cell database (UESC) - a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
(2007)Background: Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database http://scgap.systemsbiology.net/ is a public database that ... -
Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
(2005)Background: Commercially available assays to detect antibodies to the herpes simplex virus type 2 (HSV-2)-specific glycoprotein gG-2 have markedly improved serologic diagnosis of HSV-2 infection. However, even tests with ...