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Oral Antimicrobial Peptides and Biological Control of Caries

Show simple item record Dale, Beverly A. en_US Tao, Renchuan en_US Kimball, Janet R. en_US Jurevic, Richard J. en_US 2010-04-21T15:50:37Z 2010-04-21T15:50:37Z 2006 en_US
dc.identifier.citation Dale B, Tao R, Kimball J, Jurevic R. Oral Antimicrobial Peptides and Biological Control of Caries. BMC Oral Health. 2006;6(Suppl 1):S13. en_US
dc.identifier.other 10.1186/1472-6831-6-S1-S1 en_US
dc.identifier.uri en_US
dc.description.abstract The presence of antimicrobial peptides (AMPs) in saliva may be a biological factor that contributes to susceptibility or resistance to caries. This manuscript will review AMPs in saliva, consider their antimicrobial and immunomodulatory functions, and evaluate their potential role in the oral cavity for protection of the tooth surface as well as the oral mucosa. These AMPs are made in salivary gland and duct cells and have broad antimicrobial activity. Alpha-defensins and LL37 are also released by neutrophils into the gingival crevicular fluid. Both sources may account for their presence in saliva. A recent study in middle school children aimed to determine a possible correlation between caries prevalence in children and salivary concentrations of the antimicrobial peptides human beta-defensin-3 (hBD-3), the cathelicidin, LL37, and the alpha-defensins. The levels of these AMPs were highly variable in the population. While levels of LL37 and hBD-3 did not correlate with caries experience, the mean alpha-defensin level was significantly higher in children with no caries than in children with caries (p less than 0.005). We conclude that several types of AMPs that may have a role in oral health are present in unstimulated saliva. Low salivary levels of alphadefensin may represent a biological factor that contributes to caries susceptibility. Our observation could lead to new ways to prevent caries and to a new tool for caries risk assessment. en_US
dc.description.sponsorship This study was supported by grants from the national Institute of Dental and Craniofacial Research via the Northwest/Alaska Center for Research to Reduce Oral Health Disparities (U54 DE14254). en_US
dc.language.iso en_US en_US
dc.title Oral Antimicrobial Peptides and Biological Control of Caries en_US
dc.type Article en_US

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