ResearchWorks Archive
    • Login
    View Item 
    •   ResearchWorks Home
    • Faculty and Researcher Data and Papers
    • Global Health, Department of
    • Department of Global Health Faculty Papers
    • View Item
    •   ResearchWorks Home
    • Faculty and Researcher Data and Papers
    • Global Health, Department of
    • Department of Global Health Faculty Papers
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria

    Thumbnail
    View/Open
    1475-2875-7-26.pdf (295.4Kb)
    Date
    2008
    Author
    Kabyemela, Edward R.
    Muehlenbachs, Atis
    Fried, Michal
    Kurtis, Jonathan D.
    Mutabingwa, Theonest K.
    Duffy, Patrick E.
    Metadata
    Show full item record
    Abstract
    Background: Placental malaria (PM) is an important cause of maternal and foetal mortality in tropical areas, and severe sequelae and mortality are related to inflammation in the placenta. Diagnosis is difficult because PM is often asymptomatic, peripheral blood smear examination detects parasitemia as few as half of PM cases, and no peripheral markers have been validated for placental inflammation. Methods: In a cohort of Tanzanian parturients, PM was determined by placental blood smears and placental inflammation was assessed by histology and TNF mRNA levels. Maternal peripheral blood levels of several immune mediators previously implicated in PM pathogenesis, as well as ferritin and leptin were measured. The relationship between the levels of these soluble factors to PM and placental inflammation was examined. Results: Peripheral levels of TNF, TNF-RI, TNF-RII, IL-1, IL-10, and ferritin were elevated during PM, whereas levels of IFN-[gamma], IL-4, IL-5 and IL-6 were unchanged and levels of leptin were decreased. In receiver operating characteristic curve analysis, IL-10 had the greatest area under the curve, and would provide a sensitivity of 60% with a false positive rate of 10%. At a cut off level of 15 pg/mL, IL-10 would detect PM with a sensitivity of 79.5% and a specificity of 84.3%. IL-10 levels correlated with placental inflammatory cells and placental TNF mRNA levels in first time mothers. Conclusion: These data suggest that IL-10 may have utility as a biomarker for inflammatory PM in research studies, but that additional biomarkers may be required to improve clinical diagnosis and management of malaria during pregnancy.
    URI
    http://www.malariajournal.com/content/7/1/26
    http://hdl.handle.net/1773/15733
    Collections
    • Department of Global Health Faculty Papers [9]

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    @mire NV