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dc.contributor.authorJordan, Katherine C.en_US
dc.contributor.authorSchaeffer, Valerieen_US
dc.contributor.authorFischer, Karin A.en_US
dc.contributor.authorGray. Elizabeth E.en_US
dc.contributor.authorRuohola-Baker, Hanneleen_US
dc.date.accessioned2010-04-21T15:55:09Z
dc.date.available2010-04-21T15:55:09Z
dc.date.issued2006-03-16en_US
dc.identifier.citationJordan K, Schaeffer V, Fischer K, Gray E, Ruohola-Baker H. Notch signaling through Tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Developmental Biology. 2006;6(1):16.en_US
dc.identifier.other10.1186/1471-213X-6-16en_US
dc.identifier.urihttp://www.biomedcentral.com/1471-213X/6/16en_US
dc.identifier.urihttp://hdl.handle.net/1773/15767
dc.description.abstractBackground: The follicle cells of the Drosophila egg chamber provide an excellent model in which to study modulation of the cell cycle. During mid-oogenesis, the follicle cells undergo a variation of the cell cycle, endocycle, in which the cells replicate their DNA, but do not go through mitosis. Previously, we showed that Notch signaling is required for the mitotic-to-endocycle transition, through downregulating String/Cdc25, and Dacapo/p21 and upregulating Fizzy-related/Cdh1. Results: In this paper, we show that Notch signaling is modulated by Shaggy and temporally induced by the ligand Delta, at the mitotic-to-endocycle transition. In addition, a downstream target of Notch, tramtrack, acts at the mitotic-to-endocycle transition. We also demonstrate that the JNK pathway is required to promote mitosis prior to the transition, independent of the cell cycle components acted on by the Notch pathway. Conclusion: This work reveals new insights into the regulation of Notch-dependent mitotic-toendocycle switch.en_US
dc.description.sponsorshipHR-B was funded by grants from the National Institues of Health, American Heart Association and American Cancer Society. VS was supported by the Human Frontier Science Program, EEG by Washington NASA Space Grant and Mary Gates Foundation.en_US
dc.language.isoen_USen_US
dc.titleNotch signaling through Tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cellsen_US


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