Show simple item record

dc.contributor.authorPuente, Xose S.en_US
dc.contributor.authorVelasco, Gloriaen_US
dc.contributor.authorGutierrez-Fernandez, Anaen_US
dc.contributor.authorBertranpetit, Jaumeen_US
dc.contributor.authorKing, Mary-Claireen_US
dc.contributor.authorLopez-Otin, Carlosen_US
dc.date.accessioned2010-04-21T15:55:28Z
dc.date.available2010-04-21T15:55:28Z
dc.date.issued2006en_US
dc.identifier.citationPuente X, Velasco G, Gutierrez-Fernandez A, et al. Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics. 2006;7(1):15.en_US
dc.identifier.other10.1186/1471-2164-7-15en_US
dc.identifier.urihttp://www.biomedcentral.com/1471-2164/7/15en_US
dc.identifier.urihttp://hdl.handle.net/1773/15770
dc.description.abstractBackground: Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribute to their distinct cancer susceptibility, we have examined in the chimpanzee genome the orthologous genes of a set of 333 human cancer genes. Results: This analysis has revealed that all examined human cancer genes are present in chimpanzee, contain intact open reading frames and show a high degree of conservation between both species. However, detailed analysis of this set of genes has shown some differences in genes of special relevance for human cancer. Thus, the chimpanzee gene encoding p53 contains a Pro residue at codon 72, while this codon is polymorphic in humans and can code for Arg or Pro, generating isoforms with different ability to induce apoptosis or interact with p73. Moreover, sequencing of the BRCA1 gene has shown an 8 Kb deletion in the chimpanzee sequence that prematurely truncates the co-regulated NBR2 gene. Conclusion: These data suggest that small differences in cancer genes, as those found in tumor suppressor genes, might influence the differences in cancer susceptibility between human and chimpanzee. Nevertheless, further analysis will be required to determine the exact contribution of the genetic changes identified in this study to the different cancer incidence in non-human primates.en_US
dc.language.isoen_USen_US
dc.titleComparative analysis of cancer genes in the human and chimpanzee genomesen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record