Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

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Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

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dc.contributor.author Koelle, David M. en_US
dc.contributor.author Liu, Zhi en_US
dc.contributor.author McClurkan, Christopher M. en_US
dc.contributor.author Topp, Max S. en_US
dc.contributor.author Riddell, Stanley R. en_US
dc.contributor.author Pamer, Eric G. en_US
dc.contributor.author Johnson, Andrew S. en_US
dc.contributor.author Wald, Anna en_US
dc.contributor.author Corey, Lawrence en_US
dc.date.accessioned 2010-04-21T15:55:51Z
dc.date.available 2010-04-21T15:55:51Z
dc.date.issued 2002-08-15 en_US
dc.identifier.citation Koelle DM, Liu Z, McClurkan CM, et al. Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus. J Clin Invest. 2002;110(4):537-548. en_US
dc.identifier.other 10.1172/JCI15537 en_US
dc.identifier.uri http://www.jci.org/articles/view/15537 en_US
dc.identifier.uri http://hdl.handle.net/1773/15773
dc.description.abstract Virus-specific CD8+ T cells traffic to infected tissues to promote clearance of infection. We used herpes simplex virus type 2 (HSV-2) as a model system to investigate CD8+ T cell trafficking to the skin in humans. Using human leukocyte antigen (HLA) class I tetramers, we observed that HSV-specific CD8+ T cells in the peripheral blood expressed high levels of cutaneous lymphocyte-associated antigen (CLA). In contrast, CD8+ T cells specific for non–skin-tropic herpesviruses lacked CLA expression. CLA-positive HSV-2–specific CD8+ T cells had the characteristics of central memory cells, expressing CCR7, CD62L, and CD28, and they proliferated briskly in response to antigen. CLA is related to a functional E-selectin ligand, and both E-selectin and CLA-positive cells were detected in HSV-2–infected skin. HSV-2–specific T cells adhered to cells transfected with E-selectin. A higher proportion of HSV-specific CD8+ T cells recovered from herpes lesions express CLA compared with blood, consistent with a role for CLA in skin homing. To our knowledge, this is the first report of expression of tissue-specific adhesion-associated molecules by virus-specific CD8+ T cells. The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules. en_US
dc.description.sponsorship NIH grants AI-30731 and AI-50132, the Cancer Research Institute, and Deutsche Forschungsgemeinschaft grant To 208/1-1. en_US
dc.language.iso en_US en_US
dc.title Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus en_US


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