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dc.contributor.authorCuster, Brianen_US
dc.contributor.authorLongstreth Jr., W.T.en_US
dc.contributor.authorPhillips, Leslie E.en_US
dc.contributor.authorKoepsell, Thomas D.en_US
dc.contributor.authorVan Belle, Geralden_US
dc.date.accessioned2010-04-21T15:57:07Z
dc.date.available2010-04-21T15:57:07Z
dc.date.issued2006en_US
dc.identifier.citationCuster B, Longstreth WT, Phillips L, Koepsell T, Van Belle G. Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study. BMC Cancer. 2006;6(1):152.en_US
dc.identifier.other10.1186/1471-2407-6-152en_US
dc.identifier.urihttp://www.biomedcentral.com/1471-2407/6/152en_US
dc.identifier.urihttp://hdl.handle.net/1773/15783
dc.descriptionProfessor. Authors Phillips, Koepsell, and Van Belle are also UW professors/researchers.en_US
dc.description.abstractBackground: The role of exogenous hormone exposures in the development of meningioma is unclear, but these exposures have been proposed as one hypothesis to explain the over-abundance of such tumors in women. Methods: The association between oral contraception (OC) or hormone replacement therapy (HRT) and intracranial meningioma in women was investigated using a population-based, matched case-control study. Exposures for 143 cases and 286 controls matched on age within five years were obtained by interview. Diagnoses were confirmed histopathologically and estrogen and progesterone receptor assays conducted. Results: Although risk of meningioma appeared modestly elevated in past OC users (OR = 1.5, 95% CI 0.8 - 2.7), and in current users (OR = 2.5, 95% CI 0.5 - 12.6), the confidence intervals were wide. No significant association between meningioma risk and duration of OC use was found. Likewise, risk of meningioma was only weakly associated with past use of HRT (OR = 0.7, 95% CI0.4 - 1.3), and not at all with current use of HRT (OR = 1.0, 95% CI 0.5 - 2.2). Of 142 available specimens, 2 (1%) expressed estrogen receptors, whereas 130 (92%) expressed progesterone receptors (PR). OC use was associated with increased risk of a meningioma expressing less rather than more PR (OR = 3.2, 95% CI 1.3 - 8.0). Overall, in post menopausal women, HRT use appeared to confer a non-significant protective effect, and was not associated with low or high PR expressing meningiomas. Conclusion: This study found little evidence of associations between meningioma and exogenous hormone exposures in women but did suggest that some hormonal exposures may influence tumor biology in those women who develop meningioma.en_US
dc.description.sponsorshipThis study was funded by a grant (CA 60710) from the National Cancer Institute, Bethesda, Maryland, USA.en_US
dc.language.isoen_USen_US
dc.titleHormonal exposures and the risk of intracranial meningioma in women: a population-based case-control studyen_US
dc.typeArticleen_US


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