Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial[ISRCTN43479664]

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Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial[ISRCTN43479664]

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dc.contributor.author Ly, Kiet A. en_US
dc.contributor.author Milgrom, Peter en_US
dc.contributor.author Roberts, Marilyn C. en_US
dc.contributor.author Yamaguchi, David K. en_US
dc.contributor.author Rothen, Marilynn en_US
dc.contributor.author Mueller, Greg en_US
dc.date.accessioned 2010-04-21T15:58:32Z
dc.date.available 2010-04-21T15:58:32Z
dc.date.issued 2006 en_US
dc.identifier.citation Ly K, Milgrom P, Roberts M, et al. Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. BMC Oral Health. 2006;6(1):6. en_US
dc.identifier.other 10.1186/1472-6831-6-6 en_US
dc.identifier.uri http://www.biomedcentral.com/1472-6831/6/6 en_US
dc.identifier.uri http://hdl.handle.net/1773/15794
dc.description.abstract Background: Xylitol is a naturally occurring sugar substitute that has been shown to reduce the level of mutans streptococci in plaque and saliva and to reduce tooth decay. It has been suggested that the degree of reduction is dependent on both the amount and the frequency of xylitol consumption. For xylitol to be successfully and cost-effectively used in public health prevention strategies dosing and frequency guidelines should be established. This study determined the reduction in mutans streptococci levels in plaque and unstimulated saliva to increasing frequency of xylitol gum use at a fixed total daily dose of 10.32 g over five weeks. Methods: Participants (n = 132) were randomized to either active groups (10.32 g xylitol/day) or a placebo control (9.828 g sorbitol and 0.7 g maltitol/day). All groups chewed 12 pieces of gum per day. The control group chewed 4 times/day and active groups chewed xylitol gum at a frequency of 2 times/day, 3 times/day, or 4 times/day. The 12 gum pieces were evenly divided into the frequency assigned to each group. Plaque and unstimulated saliva samples were taken at baseline and five-weeks and were cultured on modified Mitis Salivarius agar for mutans streptococci enumeration. Results: There were no significant differences in mutans streptococci level among the groups at baseline. At five-weeks, mutans streptococci levels in plaque and unstimulated saliva showed a linear reduction with increasing frequency of xylitol chewing gum use at the constant daily dose. Although the difference observed for the group that chewed xylitol 2 times/day was consistent with the linear model, the difference was not significant. Conclusion: There was a linear reduction in mutans streptococci levels in plaque and saliva with increasing frequency of xylitol gum use at a constant daily dose. Reduction at a consumption frequency of 2 times per day was small and consistent with the linear-response line but was not statistically significant. en_US
dc.description.sponsorship Supported by Grant No. U54DE14254 from the National Institute of Dental and Craniofacial Research and the National Center for Minority Health and Health Disparities, NIH. en_US
dc.language.iso en_US en_US
dc.title Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial[ISRCTN43479664] en_US
dc.type Article en_US


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