Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis

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Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis

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dc.contributor.author Shavelle, David M. en_US
dc.contributor.author Buljabasic, Nediljka en_US
dc.contributor.author Takasu, Junichiro en_US
dc.contributor.author Babaie, Ashkan en_US
dc.contributor.author Rosales, Joseph en_US
dc.contributor.author Budoff, Matthew J. en_US
dc.contributor.author O'Brien, Kevin D. en_US
dc.date.accessioned 2010-05-06T20:02:07Z
dc.date.available 2010-05-06T20:02:07Z
dc.date.issued 2006 en_US
dc.identifier.citation Shavelle D, Buljabasic N, Takasu J, et al. Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis. Cardiovascular Ultrasound. 2006;4(1):12. en_US
dc.identifier.other 10.1186/1476-7120-4-12 en_US
dc.identifier.uri http://www.cardiovascularultrasound.com/content/4/1/12 en_US
dc.identifier.uri http://hdl.handle.net/1773/15809
dc.description.abstract The severity index is a new echocardiographic measure that is thought to be an accurate indicator of aortic leaflet pathology in patients with AS. However, it has not been validated against cardiac catheterization or Doppler echocardiographic measures of AS severity nor has it been applied to patients with aortic sclerosis. The purposes of this study were to compare the severity index to invasive hemodynamics and Doppler echocardiography across the spectrum of calcific aortic valve disease, including aortic sclerosis and AS. 48 patients with aortic sclerosis and AS undergoing echocardiography and cardiac catheterization comprised the study population. The aortic valve leaflets were assessed for mobility (scale 1 to 6) and calcification (scale 1 to 4) and the severity index was calculated as the sum of the mobility and calcification scores according to the methods of Bahler et al. The severity index increased with increasing severity of aortic valve disease; the severity indices for patients with aortic sclerosis, mild to moderate AS and severe AS were 3.38 � 1.06, 6.45 � 2.16 and 8.38 � 1.41, respectively. The aortic jet velocity by echocardiography and the square root of the maximum aortic valve gradient by cardiac catheterization correlated well with the severity index (r = 0.84, p less than 0.0001; r = 0.84, p less than 0.0001, respectively). These results confirm that the severity index correlates with hemodynamic severity of aortic valve disease and may prove to be a useful measure in patients with aortic sclerosis and AS. en_US
dc.description.sponsorship en_US
dc.language.iso en_US en_US
dc.title Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis en_US
dc.type Article en_US


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