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dc.contributor.authorShavelle, David M.en_US
dc.contributor.authorBuljabasic, Nediljkaen_US
dc.contributor.authorTakasu, Junichiroen_US
dc.contributor.authorBabaie, Ashkanen_US
dc.contributor.authorRosales, Josephen_US
dc.contributor.authorBudoff, Matthew J.en_US
dc.contributor.authorO'Brien, Kevin D.en_US
dc.date.accessioned2010-05-06T20:02:07Z
dc.date.available2010-05-06T20:02:07Z
dc.date.issued2006en_US
dc.identifier.citationShavelle D, Buljabasic N, Takasu J, et al. Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis. Cardiovascular Ultrasound. 2006;4(1):12.en_US
dc.identifier.other10.1186/1476-7120-4-12en_US
dc.identifier.urihttp://www.cardiovascularultrasound.com/content/4/1/12en_US
dc.identifier.urihttp://hdl.handle.net/1773/15809
dc.description.abstractThe severity index is a new echocardiographic measure that is thought to be an accurate indicator of aortic leaflet pathology in patients with AS. However, it has not been validated against cardiac catheterization or Doppler echocardiographic measures of AS severity nor has it been applied to patients with aortic sclerosis. The purposes of this study were to compare the severity index to invasive hemodynamics and Doppler echocardiography across the spectrum of calcific aortic valve disease, including aortic sclerosis and AS. 48 patients with aortic sclerosis and AS undergoing echocardiography and cardiac catheterization comprised the study population. The aortic valve leaflets were assessed for mobility (scale 1 to 6) and calcification (scale 1 to 4) and the severity index was calculated as the sum of the mobility and calcification scores according to the methods of Bahler et al. The severity index increased with increasing severity of aortic valve disease; the severity indices for patients with aortic sclerosis, mild to moderate AS and severe AS were 3.38 � 1.06, 6.45 � 2.16 and 8.38 � 1.41, respectively. The aortic jet velocity by echocardiography and the square root of the maximum aortic valve gradient by cardiac catheterization correlated well with the severity index (r = 0.84, p less than 0.0001; r = 0.84, p less than 0.0001, respectively). These results confirm that the severity index correlates with hemodynamic severity of aortic valve disease and may prove to be a useful measure in patients with aortic sclerosis and AS.en_US
dc.description.sponsorshipen_US
dc.language.isoen_USen_US
dc.titleValidation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosisen_US
dc.typeArticleen_US


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