Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection

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Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection

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dc.contributor.author Boriskin, Yury S. en_US
dc.contributor.author P�cheur, Eve-Isabelle en_US
dc.contributor.author Polyak, Stephen J. en_US
dc.date.accessioned 2010-05-06T20:03:22Z
dc.date.available 2010-05-06T20:03:22Z
dc.date.issued 2006 en_US
dc.identifier.citation Boriskin Y, Pecheur E, Polyak S. Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection. Virology Journal. 2006;3(1):56. en_US
dc.identifier.other 10.1186/1743-422X-3-56 en_US
dc.identifier.uri http://www.virologyj.com/content/3/1/56 en_US
dc.identifier.uri http://hdl.handle.net/1773/15820
dc.description.abstract Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its effect on hepatitis C virus (HCV) infection and replication in cell culture. Long-term ARB treatment of Huh7 cells chronically replicating a genomic length genotype 1b replicon resulted in sustained reduction of viral RNA and protein expression, and eventually cured HCV infected cells. Pre-treatment of human hepatoma Huh7.5.1 cells with 15 [micro]M ARB for 24 to 48 hours inhibited acute infection with JFH-1 virus by up to 1000-fold. The inhibitory effect of ARB on HCV was not due to generalized cytotoxicity, nor to augmentation of IFN antiviral signaling pathways, but involved impaired virus-mediated membrane fusion. ARB's affinity for membranes may inhibit several aspects of the HCV lifecycle that are membrane-dependent. en_US
dc.description.sponsorship YSB was partially supported by the Fulbright Visiting Scholar Program. SJP is supported by NIH grants RO1 DK62187 and U19 A1066328, and EIP is supported by a grant from the ANRS (Agence Nationale de Recherche contre le SIDA et les H�patites virales). en_US
dc.language.iso en_US en_US
dc.subject en_US
dc.title Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection en_US
dc.type Article en_US


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