Show simple item record

dc.contributor.authorBoriskin, Yury S.en_US
dc.contributor.authorP�cheur, Eve-Isabelleen_US
dc.contributor.authorPolyak, Stephen J.en_US
dc.date.accessioned2010-05-06T20:03:22Z
dc.date.available2010-05-06T20:03:22Z
dc.date.issued2006en_US
dc.identifier.citationBoriskin Y, Pecheur E, Polyak S. Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection. Virology Journal. 2006;3(1):56.en_US
dc.identifier.other10.1186/1743-422X-3-56en_US
dc.identifier.urihttp://www.virologyj.com/content/3/1/56en_US
dc.identifier.urihttp://hdl.handle.net/1773/15820
dc.description.abstractArbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its effect on hepatitis C virus (HCV) infection and replication in cell culture. Long-term ARB treatment of Huh7 cells chronically replicating a genomic length genotype 1b replicon resulted in sustained reduction of viral RNA and protein expression, and eventually cured HCV infected cells. Pre-treatment of human hepatoma Huh7.5.1 cells with 15 [micro]M ARB for 24 to 48 hours inhibited acute infection with JFH-1 virus by up to 1000-fold. The inhibitory effect of ARB on HCV was not due to generalized cytotoxicity, nor to augmentation of IFN antiviral signaling pathways, but involved impaired virus-mediated membrane fusion. ARB's affinity for membranes may inhibit several aspects of the HCV lifecycle that are membrane-dependent.en_US
dc.description.sponsorshipYSB was partially supported by the Fulbright Visiting Scholar Program. SJP is supported by NIH grants RO1 DK62187 and U19 A1066328, and EIP is supported by a grant from the ANRS (Agence Nationale de Recherche contre le SIDA et les H�patites virales).en_US
dc.language.isoen_USen_US
dc.titleArbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infectionen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record