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Immunostimulation and Immunoinhibition of Premalignant Lesions

Show simple item record Prehn, Richmond T. en_US 2010-05-06T20:04:00Z 2010-05-06T20:04:00Z 2007 en_US
dc.identifier.citation Prehn R. Immunostimulation and Immunoinhibition of Premalignant Lesions. Theoretical Biology and Medical Modelling. 2007;4(1):6. en_US
dc.identifier.other 10.1186/1742-4682-4-6 en_US
dc.identifier.uri en_US
dc.description.abstract Background: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. Hypothesis: A tumor-stimulatory immune response may be essential for survival of a neoplasm in vivo and for the biological progression from a premalignant lesion to a malignancy. Neither a positive nor a negative correlation between the magnitude of an immune-cell infiltrate and a cancer's prognosis can reveal whether the infiltrate was stimulating or inhibiting to the tumor's growth unless the position on the nonlinear curve that relates tumor growth to the magnitude of the immune reaction is known. Discussion: This hypothesis is discussed in relation to the development of human malignant melanomas and colorectal cancers. en_US
dc.description.sponsorship en_US
dc.language.iso en_US en_US
dc.title Immunostimulation and Immunoinhibition of Premalignant Lesions en_US
dc.type Article en_US

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