Technology Development to Explore the Relationship Between Oral Health and the Oral Microbial Community

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Technology Development to Explore the Relationship Between Oral Health and the Oral Microbial Community

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dc.contributor.author Starke, E. Michelle en_US
dc.contributor.author Smoot, James C. en_US
dc.contributor.author Smoot, Laura M. en_US
dc.contributor.author Liu, Wen-Tso en_US
dc.contributor.author Chandler, Darrell P. en_US
dc.contributor.author Lee, Hyun H. en_US
dc.contributor.author Stahl, David A. en_US
dc.date.accessioned 2010-05-06T20:06:37Z
dc.date.available 2010-05-06T20:06:37Z
dc.date.issued 2006 en_US
dc.identifier.citation Starke EM, Smoot J, Smoot L, et al. Technology Development to Explore the Relationship Between Oral Health and the Oral Microbial Community. BMC Oral Health. 2006;6(Suppl 1):S10. en_US
dc.identifier.other 10.1186/1472-6831-6-S1-S1 en_US
dc.identifier.uri http://www.biomedcentral.com/1472-6831/6/S1/S10 en_US
dc.identifier.uri http://hdl.handle.net/1773/15849
dc.description.abstract The human oral cavity contains a complex microbial community that, until recently, has not been well characterized. Studies using molecular tools have begun to enumerate and quantify the species residing in various niches of the oral cavity; yet, virtually every study has revealed additional new species, and little is known about the structural dynamics of the oral microbial community or how it changes with disease. Current estimates of bacterial diversity in the oral cavity range up to 700 species, although in any single individual this number is much lower. Oral microbes are responsible for common chronic diseases and are suggested to be sentinels of systemic human diseases. Microarrays are now being used to study oral microbiota in a systematic and robust manner. Although this technology is still relatively young, improvements have been made in all aspects of the technology, including advances that provide better discrimination between perfect-match hybridizations from non-specific (and closely-related) hybridizations. This review addresses a core technology using gel-based microarrays and the initial integration of this technology into a single device needed for system-wide studies of complex microbial community structure and for the development of oral diagnostic devices. en_US
dc.description.sponsorship Grants from National Institutes of Health (NIH)/NIDCR (U01 DE14955) to DAS, LMS and EMLS; NIH (5R01AI059517) to DPC; NASA (MSMT-2004-0045-0066) to DAS, JCS and HHL; US DARPA (DABT63-99-1-0009) to DAS and JCS. en_US
dc.language.iso en_US en_US
dc.title Technology Development to Explore the Relationship Between Oral Health and the Oral Microbial Community en_US
dc.type Article en_US


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