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dc.contributor.authorStarke, E. Michelleen_US
dc.contributor.authorSmoot, James C.en_US
dc.contributor.authorSmoot, Laura M.en_US
dc.contributor.authorLiu, Wen-Tsoen_US
dc.contributor.authorChandler, Darrell P.en_US
dc.contributor.authorLee, Hyun H.en_US
dc.contributor.authorStahl, David A.en_US
dc.date.accessioned2010-05-06T20:06:37Z
dc.date.available2010-05-06T20:06:37Z
dc.date.issued2006en_US
dc.identifier.citationStarke EM, Smoot J, Smoot L, et al. Technology Development to Explore the Relationship Between Oral Health and the Oral Microbial Community. BMC Oral Health. 2006;6(Suppl 1):S10.en_US
dc.identifier.other10.1186/1472-6831-6-S1-S1en_US
dc.identifier.urihttp://www.biomedcentral.com/1472-6831/6/S1/S10en_US
dc.identifier.urihttp://hdl.handle.net/1773/15849
dc.description.abstractThe human oral cavity contains a complex microbial community that, until recently, has not been well characterized. Studies using molecular tools have begun to enumerate and quantify the species residing in various niches of the oral cavity; yet, virtually every study has revealed additional new species, and little is known about the structural dynamics of the oral microbial community or how it changes with disease. Current estimates of bacterial diversity in the oral cavity range up to 700 species, although in any single individual this number is much lower. Oral microbes are responsible for common chronic diseases and are suggested to be sentinels of systemic human diseases. Microarrays are now being used to study oral microbiota in a systematic and robust manner. Although this technology is still relatively young, improvements have been made in all aspects of the technology, including advances that provide better discrimination between perfect-match hybridizations from non-specific (and closely-related) hybridizations. This review addresses a core technology using gel-based microarrays and the initial integration of this technology into a single device needed for system-wide studies of complex microbial community structure and for the development of oral diagnostic devices.en_US
dc.description.sponsorshipGrants from National Institutes of Health (NIH)/NIDCR (U01 DE14955) to DAS, LMS and EMLS; NIH (5R01AI059517) to DPC; NASA (MSMT-2004-0045-0066) to DAS, JCS and HHL; US DARPA (DABT63-99-1-0009) to DAS and JCS.en_US
dc.language.isoen_USen_US
dc.titleTechnology Development to Explore the Relationship Between Oral Health and the Oral Microbial Communityen_US
dc.typeArticleen_US


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