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Associations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study

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dc.contributor.author Qiu, Chunfang en_US
dc.contributor.author Sanchez, Sixto E. en_US
dc.contributor.author Lam, Nelly en_US
dc.contributor.author Garcia, Pedro en_US
dc.contributor.author Williams, Michelle A. en_US
dc.date.accessioned 2010-05-06T20:09:58Z
dc.date.available 2010-05-06T20:09:58Z
dc.date.issued 2007 en_US
dc.identifier.citation Qiu C, Sanchez S, Lam N, Garcia P, Williams M. Associations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study. BMC Women's Health. 2007;7(1):15. en_US
dc.identifier.other 10.1186/1472-6874-7-15 en_US
dc.identifier.uri http://www.biomedcentral.com/1472-6874/7/15 en_US
dc.identifier.uri http://hdl.handle.net/1773/15880
dc.description.abstract Background: Preeclampsia involves endothelial dysfunction, platelet dysfunction/activation and sympathetic over-activity similar to cardiovascular disorders (CVD). Depression, an independent risk factor for progression of CVD, was found to be associated with an increased risk of preeclampsia among Finnish women. We examined the relation between depression/depressive symptoms and preeclampsia risk among Peruvian women. Methods: The study included 339 preeclamptic cases and 337 normotensive controls. Depression and depressive symptoms during pregnancy were assessed using the Patient Health Questionnaire (PHQ-9). Odds ratios (OR) and 95% confidence intervals (CI) were estimated from logistic regression models. Results: The prevalence of moderate depression was 11.5% among cases and 5.3% among controls. The corresponding figures for moderate-severe depression were 3.5% for cases and 2.1% for controls. Compared with non-depressed women, those with moderate depression had a 2.3- fold increased risk of preeclampsia (95% CI: 1.2�4.4), while moderate-severe depression was associated with a 3.2-fold (95% CI: 1.1�9.6) increased risk of preeclampsia. Associations of each of the 9-items of the PHQ-9 depression screening module with preeclampsia risk were also observed. Conclusion: Our findings are consistent with the only other published report on this topic. Collectively, available data support recent calls for expanded efforts to study and address depression among pregnant women. en_US
dc.description.sponsorship This research was supported in part by awards from the National Institutes of Health (T37 MD001449-09) and the Bill and Melinda Gates Foundation. en_US
dc.language.iso en_US en_US
dc.title Associations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study en_US
dc.type Article en_US


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