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dc.contributor.authorUnderhill, Hunter R.en_US
dc.contributor.authorYuan, Chunen_US
dc.contributor.authorTerry, James G.en_US
dc.contributor.authorChen, Haiyingen_US
dc.contributor.authorEspeland, Mark A.en_US
dc.contributor.authorHatsukami, Thomas S.en_US
dc.contributor.authorSaam, Tobiasen_US
dc.contributor.authorChu, Baochengen_US
dc.contributor.authorYu, Weien_US
dc.contributor.authorOikawa, Minakoen_US
dc.contributor.authorTakaya, Norihideen_US
dc.contributor.authorYarnykh, Vasily L.en_US
dc.contributor.authorKraft, Roberten_US
dc.contributor.authorCarr, J. Jeffreyen_US
dc.contributor.authorMaldjian, Josephen_US
dc.contributor.authorTang, Rongen_US
dc.contributor.authorCrouse III, John R.en_US
dc.date.accessioned2010-05-06T20:10:23Z
dc.date.available2010-05-06T20:10:23Z
dc.date.issued2008en_US
dc.identifier.citationUnderhill H, Yuan C, Terry J, et al. Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: A cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance. 2008;10(1):31.en_US
dc.identifier.other10.1186/1532-429X-10-31en_US
dc.identifier.urihttp://jcmr-online.com/content/10/1/31en_US
dc.identifier.urihttp://hdl.handle.net/1773/15884
dc.description.abstractObjective: We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, = 50% stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). Methods and results: 191 participants (50.3% female; 50.8% CAD cases) were imaged with a multi-sequence, carotid CMR protocol at 1.5T. For each segment of the carotid, lumen area, wall area, total vessel area (lumen area + wall area), mean wall thickness and the presence or absence of calcification and lipid-rich necrotic core were recorded bilaterally. In male CAD cases compared to male controls, the distal bulb had a significantly smaller lumen area (60.0 [plus or minus] 3.1 vs. 79.7 [plus or minus] 3.2 mm[super]2, p less than 0.001) and total vessel area (99.6 [plus or minus] 4.0 vs. 119.8 [plus or minus] 4.1 mm[super]2; p less than 0.001), and larger mean wall thickness (1.25 [plus or minus] 0.03 vs. 1.11 [plus or minus] 0.03 mm; p = 0.002). Similarly, the internal carotid had a smaller lumen area (37.5 [plus or minus] 1.8 vs. 44.6 [plus or minus] 1.8 mm[super]2; p = 0.006) and smaller total vessel area (64.0 [plus or minus] 2.3 vs. 70.9 [plus or minus] 2.4 mm[super]2; p = 0.04). These metrics were not significantly different between female groups in the distal bulb and internal carotid or for either gender in the common carotid. Male CAD cases had an increased prevalence of lipid-rich necrotic core (49.0% vs. 19.6%; p = 0.003), while calcification was more prevalent in both male (46.9% vs. 17.4%; p = 0.002) and female (33.3% vs. 14.6%; p = 0.031) CAD cases compared to controls. Conclusion: Males with obstructive CAD compared to male controls had carotid bulbs and internal carotid arteries with smaller total vessel and lumen areas, and an increased prevalence of lipid-rich necrotic core. Carotid calcification was related to CAD status in both males and females. Carotid CMR identifies distinct morphological and compositional differences in the carotid arteries between individuals with and without angiographically-defined obstructive CAD.en_US
dc.description.sponsorshipCarotid Atherosclerosis (MRI) Progression Study (CAMPS, HL076378) and Cardiovascular Research Training Program (T-32, HL07838); and the General Clinical Research Center at the Wake Forest University School of Medicine (M01 RR-07122).en_US
dc.language.isoen_USen_US
dc.titleDifferences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: A cardiovascular magnetic resonance studyen_US
dc.typeArticleen_US


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