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Gone with the Wnts…. The Wnt Signaling Pathway in Pleurobrachia bachei
Wnt signaling is known to be critical for proper embryonic development in most animals studied to date15. But key evolutionary questions on the origin and evolution of this pathway in the metazoan common ancestor are still unresolved. Recently, the genome of Pleurobrachia bachei, a member of the early branching metazoan ...
Collagen type IV in the Ctenophore Pleurobrachia bachei
The evolution of multicellular animals required the development of epithelial tissues that function in controlling the transport of molecules from one environment to another. Collagen proteins are crucial to the formation of epithelial tissues, and are therefore critical in understanding the origins of multicellularity and ...
Out on a LIM: LIM homeobox genes in the ctenophore Pleurobrachia bachei
LIM homeobox (Lhx) gene family consists of six subfamilies of patterning genes which play a major role in the development of the nervous system and are found only in animals. We looked at their presence and expression in the ctenophore Pleurobrachia bachei to study their evolution and development. Ctenophores are among the ...
Brachyury expression in the adult ctenophore, Pleurobrachia bachei
Brachyury is a transcription factor important for mesoderm formation in chordates. Ctenophores are basal metazoans with little known about their germ layer organization. For this reason, brachyury was used as a possible mesodermal marker in the ctenophore Pleurobrachia bachei . The gene was cloned and then used for in situ ...
The Origins of Neurons and use of Glutamatergic Signaling in the Ctenophore: Pleurobrachia bachei
Ctnenophores are a group of marine, jelly like, comb bearing metazoans. This phylum consists of an estimated 100-‐200 species (Mills CE, 2012). Ctenophores are similar to cnidarians in that they have a homologous mesoderm consisting of a jelly like substance called mesoglea. They ...
A Quest for novel Signaling Molecules in Pleurobrachia Bachei
The evolution of the nervous system is poorly understood, with broad implications in basic neuroscience and regenerative medicine. The unintuitive nervous system of the basal Ctenophores provides an insight into neuronal evolution. We developed a Zero-Click computational pipeline for secretory peptide prediction from raw ...