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Origin of the Gonad: A phylogenetic analysis of SoxB1 Tracing back human sex-determining gene Sry to an orthologue involved in echinoid metamorphosis
(Friday Harbor Laboratories, 2013-06)
Until twenty-five years ago, the sex determining factor in humans had yet to be identified. The Sox family of transcription factors were identified after the human sex-determining gene SRY was sequenced and compared to other genomes (Bowles et al., 2000). SOX genes have been discovered across the Metazoans but with varying ...