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dc.contributor.authorBaker, Laura D.
dc.contributor.authorFrank, Laura L.
dc.contributor.authorFoster-Schubert, Karen
dc.contributor.authorGreen, Pattie S.
dc.contributor.authorWilkinson, Charles W.
dc.contributor.authorMcTiernan, Anne
dc.contributor.authorCholerton, Brenna A.
dc.contributor.authorPlymate, Stephen R.
dc.contributor.authorFishel, Mark A.
dc.contributor.authorWatson, G. Stennis
dc.contributor.authorDuncan, Glen E.
dc.contributor.authorMehta, Pankaj D.
dc.contributor.authorCraft, Suzanne
dc.date.accessioned2011-11-07T21:18:12Z
dc.date.available2011-11-07T21:18:12Z
dc.date.issued2010
dc.identifier.citationJ Alzheimers Dis. 2010 ; 22(2): 569–579. doi:10.3233/JAD-2010-100768.en_US
dc.identifier.urihttp://hdl.handle.net/1773/18741
dc.description.abstractImpaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise for physical health are well-documented, exercise effects on cognition have not been examined for older adults with poor glucose regulation associated with prediabetes and early T2DM. Using a randomized controlled design, twenty-eight adults (57–83 y old) meeting 2-h tolerance test criteria for glucose intolerance completed 6 months of aerobic exercise or stretching, which served as the control. The primary cognitive outcomes included measures of executive function (Trails B, Task Switching, Stroop, Self-ordered Pointing Test, and Verbal Fluency). Other outcomes included memory performance (Story Recall, List Learning), measures of cardiorespiratory fitness obtained via maximal-graded exercise treadmill test, glucose disposal during hyperinsulinemic-euglycemic clamp, body fat, and fasting plasma levels of insulin, cortisol, brain-derived neurotrophic factor, insulin-like growth factor-1, amyloid-β (Aβ40 and Aβ42). Six months of aerobic exercise improved executive function (MANCOVA, p = 0.04), cardiorespiratory fitness (MANOVA, p = 0.03), and insulin sensitivity (p = 0.05). Across all subjects, 6-month changes in cardiorespiratory fitness and insulin sensitivity were positively correlated (p = 0.01). For Aβ42, plasma levels tended to decrease for the aerobic group relative to controls (p = 0.07). The results of our study using rigorous controlled methodology suggest a cognition-enhancing effect of aerobic exercise for older glucose intolerant adults. Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline.en_US
dc.publisherJOURNAL OF ALZHEIMER'S DISEASEen_US
dc.subjectAerobic exercise; Alzheimer’s disease; cognition; dementia; diabetes; executive function; glucose intolerance; prediabetesen_US
dc.titleAerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer’s Diseaseen_US
dc.typeArticleen_US


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