Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia
Date
2008-02-15Author
Al-Noori, Salwa
Sanders, Nicole M.
Wilkinson, Charles W.
Figlewicz, Dianne P.
Taborsky Jr., Gerald J.
Metadata
Show full item recordAbstract
The posterior paraventricular nucleus of the thalamus (THPVP) has been identified as a forebrain
region that modulates the central nervous system (CNS) response to recurrent experiences of
stressors. The THPVP is activated in response to a single (SH) or recurrent (RH) experience of the
metabolic stress of hypoglycemia. In this study, we evaluated whether temporary experimental
inactivation of the THPVP would modify the neuroendocrine response to SH or RH. Infusion of
lidocaine (LIDO) or vehicle had no effect on the neuroendocrine response to SH, comparable to
findings with other stressors. THPVP vehicle infusion concomitant with RH resulted in a prevention
of the expected impairment of neuroendocrine responses, relative to SH. LIDO infusion with RH
resulted in significantly decreased glucagon and sympathoadrenal responses, relative to SH. These
results suggest that the THPVP may contribute to the sympathoadrenal stimulation induced by
hypoglycemia; and emphasizes that the THPVP is a forebrain region that may contribute to the
coordinated CNS response to metabolic stressors.