Show simple item record

dc.contributor.authorRasmussen, Dennis D.
dc.contributor.authorWilkinson, Charles W.
dc.contributor.authorRaskind, Murray A.
dc.date.accessioned2011-11-22T21:32:25Z
dc.date.available2011-11-22T21:32:25Z
dc.date.issued2006-04
dc.identifier.urihttp://hdl.handle.net/1773/19314
dc.description.abstractWe have reported that repetitive daily ethanol consumption increased anxiety-like behavior in rats 4 weeks after ethanol consumption had ceased, consistent with the persistently increased anxiety exhibited by abstinent alcoholics. Increased anxiety is associated with sym-pathoadrenal activation, so we have now also investigated ethanol-induced persistent changes in basal and stress-induced plasma epinephrine (E) and norepinephrine (NE) levels. Male Sprague-Dawley rats received liquid diet containing ethanol versus pair-fed isocaloric control liquid diet for 9 weeks. After 5 weeks’ subsequent ‘‘abstinence’’ (i.e., no ethanol in the diet), the control rats exhibited low basal plasma E and NE, which were both increased by 150–300% within 5 min after transfer to a novel cage in a novel room, returning toward basal levels within 15 min. ‘‘Abstinent’’ ethanol-treated rats exhibited elevated basal E levels (195% of controls, P < .05), which were not significantly altered by transfer to novel environment; basal NE levels tended (P < .07) to be elevated and likewise were not altered by novel environment. These results suggest that daily ethanol consumption can induce persistent increases in sympathoadrenal activation during subsequent ‘‘abstinence,’’ which are relatively refractory to further stimulation.en_US
dc.language.isoen_USen_US
dc.publisherAlcoholen_US
dc.subjectalcoholen_US
dc.subjectethanolen_US
dc.subjectstressen_US
dc.subjectepinephrineen_US
dc.subjectabstinenceen_US
dc.subjectNorepinephrine;en_US
dc.titleChronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during ‘‘abstinence’’en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record