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Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo

Show simple item record Peretz, Alon Sullivan, Jeffrey H. Leotta, Daniel F. Trenga, Carol A. Sands, Fiona F. Allen, Jason Carlsten, Chris Wilkinson, Charles W. Gill, Edward A. Kaufman, Joel D. 2011-11-23T20:39:28Z 2011-11-23T20:39:28Z 2008-07-07
dc.description.abstract BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel exhaust (DE) is a major source of traffic-related air pollution. OBJECTIVES: Our goal was to study the effects of short-term exposure to DE on vascular reactivity and on mediators of vascular tone. METHODS: In a double-blind, crossover, controlled exposure study, 27 adult volunteers (10 healthy and 17 with metabolic syndrome) were exposed in randomized order to filtered air (FA) and each of two levels of diluted DE (100 or 200 μg/m3 of fine particulate matter) in 2-hr sessions. Before and after each exposure, we assessed the brachial artery diameter (BAd) by B-mode ultrasound and collected blood samples for endothelin-1 (ET-1) and catecholamines. Postexposure we also assessed endothelium-dependent flow-mediated dilation (FMD). RESULTS: Compared with FA, DE at 200 μg/m3 elicited a decrease in BAd (0.11 mm; 95% confidence interval, 0.02–0.18), and the effect appeared linearly dose related with a smaller effect at 100 μg/m3. Plasma levels of ET-1 increased after 200 μg/m3 DE but not after FA (p = 0.01). There was no consistent impact of DE on plasma catecholamines or FMD. CONCLUSIONS: These results demonstrate that short-term exposure to DE is associated with acute endothelial response and vasoconstriction of a conductance artery. Elucidation of the signaling pathways controlling vascular tone that underlie this observation requires further study. en_US
dc.language.iso en_US en_US
dc.publisher Environmental Health Perspectives en_US
dc.subject air pollution en_US
dc.subject brachial artery en_US
dc.subject catecholamines, en_US
dc.subject endothelin-1 en_US
dc.subject vasoconstriction en_US
dc.title Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo en_US
dc.type Article en_US

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