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dc.contributor.authorLeverenz, James P.
dc.contributor.authorWilkinson, Charles W.
dc.contributor.authorWamble, Molly
dc.contributor.authorCorbin, Shannon
dc.contributor.authorGrabber, Jo Ellen
dc.contributor.authorRaskind, Murray A.
dc.contributor.authorRaskind, Elaine R.
dc.date.accessioned2011-11-23T20:47:13Z
dc.date.available2011-11-23T20:47:13Z
dc.date.issued1999-03-15
dc.identifier.urihttp://hdl.handle.net/1773/19321
dc.description.abstractChronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may lower the threshold for hippocampal neuronal degeneration in human aging and Alzheimer’s disease. Here, we asked whether chronic administration of high-dose cortisol to older nonhuman primates decreases hippocampal neuronal number as assessed by unbiased stereological counting methodology. Sixteen Macaca nemestrina (pigtailed macaques) from 18 to 29 years of age were age-, sex-, and weight-matched into pairs and randomized to receive either high-dose oral hydrocortisone (cortisol) acetate (4–6 mg/kg/d) or placebo in twice daily palatable treats for 12 months. Hypothalamic–pituitary–adrenal activity was monitored by measuring plasma adrenocorticotropin and cortisol, 24 hr urinary cortisol, and CSF cortisol. Urinary, plasma, and CSF cortisol were elevated, and plasma adrenocorticotropin was reduced in the active treatment group. Total hippocampal volume, subfield volumes, subfield neuronal density, and subfield total neuronal number did not differ between the experimental groups. These findings suggest that chronically elevated cortisol concentrations, in the absence of stress, do not produce hippocampal neuronal loss in nonhuman primates.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Neuroscienceen_US
dc.subjectcortisolen_US
dc.subjectagingen_US
dc.subjectnonhuman primateen_US
dc.subjecthippocampusen_US
dc.subjectstereologyen_US
dc.subjectCSF cortisolen_US
dc.titleEffect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primatesen_US
dc.typeArticleen_US


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