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Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates

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dc.contributor.author Leverenz, James P.
dc.contributor.author Wilkinson, Charles W.
dc.contributor.author Wamble, Molly
dc.contributor.author Corbin, Shannon
dc.contributor.author Grabber, Jo Ellen
dc.contributor.author Raskind, Murray A.
dc.contributor.author Raskind, Elaine R.
dc.date.accessioned 2011-11-23T20:47:13Z
dc.date.available 2011-11-23T20:47:13Z
dc.date.issued 1999-03-15
dc.identifier.uri http://hdl.handle.net/1773/19321
dc.description.abstract Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may lower the threshold for hippocampal neuronal degeneration in human aging and Alzheimer’s disease. Here, we asked whether chronic administration of high-dose cortisol to older nonhuman primates decreases hippocampal neuronal number as assessed by unbiased stereological counting methodology. Sixteen Macaca nemestrina (pigtailed macaques) from 18 to 29 years of age were age-, sex-, and weight-matched into pairs and randomized to receive either high-dose oral hydrocortisone (cortisol) acetate (4–6 mg/kg/d) or placebo in twice daily palatable treats for 12 months. Hypothalamic–pituitary–adrenal activity was monitored by measuring plasma adrenocorticotropin and cortisol, 24 hr urinary cortisol, and CSF cortisol. Urinary, plasma, and CSF cortisol were elevated, and plasma adrenocorticotropin was reduced in the active treatment group. Total hippocampal volume, subfield volumes, subfield neuronal density, and subfield total neuronal number did not differ between the experimental groups. These findings suggest that chronically elevated cortisol concentrations, in the absence of stress, do not produce hippocampal neuronal loss in nonhuman primates. en_US
dc.language.iso en_US en_US
dc.publisher Journal of Neuroscience en_US
dc.subject cortisol en_US
dc.subject aging en_US
dc.subject nonhuman primate en_US
dc.subject hippocampus en_US
dc.subject stereology en_US
dc.subject CSF cortisol en_US
dc.title Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates en_US
dc.type Article en_US


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