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Browsing Laboratory medicine by Subject "Molecular biology"
Now showing items 1-7 of 7
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Accurate quantification of placental (fetal) fraction by tissue specific cell-free DNA analysis.
Background:Noninvasive liquid biopsy analytes such as cell-free DNA (cfDNA) have advanced the field of precision medicine. It is most widely used in noninvasive prenatal testing (NIPT) to screen for untreatable aneuploidies ... -
Contributions and Evolutionary Potential of ampC Mutations to confer Aztreonam Resistance in Pseudomonas aeruginosa
Aztreonam is a synthetic monobactam antibiotic that is increasingly used for chronic suppressive therapy in Cystic Fibrosis (CF) patients with Pseudomonas aeruginosa airway infection. P. aeruginosa can accumulate mutations ... -
Detection of MegaTAL-induced HIV pol Mutation By Droplet Digital PCR
Reliable detection of low-level mutations in HIV-1 provirus is still a challenge. Current methods regularly used in laboratories, Surveyor assay and bulk sequencing, only have a limit of detection about 10 ~ 20%. In the ... -
Hedgehog signaling in Joubert syndrome
Joubert syndrome (JS) is a mostly recessive, neurodevelopmental condition diagnosed by the molar tooth sign (MTS) on axial brain imaging. Currently, >40 genes are associated with JS, all of which encode proteins that ... -
Highly Saturated Transposon Sequencing identifies genes impacting Staphylococcus aureus pathogenesis in macrophages
Staphylococcus aureus is a facultative intracellular pathogen in many host cell types,facilitating its persistence in chronic infections. The genes contributing to intracellular pathogenesis have not yet been fully enumerated. ... -
Regulation of Phenotypic Heterogeneity in Salmonella: Bifunctional Regulators, RcsB and YifA, Shape Flagellar Bistability
Heterogeneous expression of flagellar and invasion genes is crucial for Salmonella virulence. Such a division of labor enables an invasive subpopulation to trigger inflammation in the infected host and alter the gut ... -
Understanding Ovarian Cancer Risk: Pathogenic TP53 mutation burden in peritoneal fluid is associated with BRCA germline mutation status
Individuals with germline BRCA1 and BRCA2 mutations (BRCA carriers) have an increased risk of developing high-grade serous ovarian cancer (HGSOC), the most common and deadliest subtype of ovarian cancer. While HGSOC is ...