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dc.contributor.authorAntia, Rustomen_US
dc.contributor.authorBergstrom, Carl T.en_US
dc.contributor.authorPilyugin, Sergei S.en_US
dc.contributor.authorKaech, Susan M.en_US
dc.contributor.authorAhmed, Rafien_US
dc.date.accessioned2004-10-21T23:12:28Zen_US
dc.date.accessioned2007-06-13T19:57:49Z
dc.date.available2004-10-21T23:12:28Zen_US
dc.date.available2007-06-13T19:57:49Z
dc.date.issued2003en_US
dc.identifier.citationR. Antia, C. T. Bergstrom, S. S. Pilyugin, S. M. Keach, and R. Ahmed . 2003. Journal of Theoretical Biology. 221:585-598en_US
dc.identifier.issn0022-5193en_US
dc.identifier.urihttp://hdl.handle.net/1773/1990en_US
dc.description.abstractRecent experimental results show that even brief stimulation with antigen can cause antigenspecic CD8 T-cells to undergo sustained proliferation followed by differentiation into memory cells. These results show that the dynamics of these immune responses are not governed by constant monitoring of antigen levels, but rather that following stimulation immune cells commit to a "program". At present relatively little is known about the program which governs CD8 cell proliferation and differentiation. For example, we do not know whether the program is completely specified by the initial encounter of a T cell with antigen, or whether it subsequently can be modified by the amount of antigen present. Nor do we know whether the entire program for T cell proliferation and differentiation resides within the T cell itself, or whether some component(s) of the program are determined by cells or molecules external to the CD8 cell. In this paper we construct simple mathematical models which incorporate antigen-independent proliferation and differentiation of CD8 cells during acute infections. We use these models to determine what characteristics the program must have in order to be consistent with the existing data on the dynamics of CD8 responses, and in particular to answer the questions posed above. Our results suggest that the program is not completely de ned by the initial encounter of T cell with antigen but may be augmented by exposure to antigen in a brief window shortly after infection; furthermore, parts of the program may reside external to the T-cells. Finally we examine some of the consequences of the program for pathogen host coevolution.en_US
dc.format.extent285052 bytesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherElsevier Scienceen_US
dc.subjectimmunologyen_US
dc.subjectCD8+ cellsen_US
dc.subjectpartial differential equationsen_US
dc.subjectprogram modelen_US
dc.titleModels of CD8+ Responses: 1. What is the Antigen-independent Proliferation Programen_US
dc.typeArticleen_US


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