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Models of CD8+ Responses: 1. What is the Antigen-independent Proliferation Program

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dc.contributor.author Antia, Rustom en_US
dc.contributor.author Bergstrom, Carl T. en_US
dc.contributor.author Pilyugin, Sergei S. en_US
dc.contributor.author Kaech, Susan M. en_US
dc.contributor.author Ahmed, Rafi en_US
dc.date.accessioned 2004-10-21T23:12:28Z en_US
dc.date.accessioned 2007-06-13T19:57:49Z
dc.date.available 2004-10-21T23:12:28Z en_US
dc.date.available 2007-06-13T19:57:49Z
dc.date.issued 2003 en_US
dc.identifier.citation R. Antia, C. T. Bergstrom, S. S. Pilyugin, S. M. Keach, and R. Ahmed . 2003. Journal of Theoretical Biology. 221:585-598 en_US
dc.identifier.issn 0022-5193 en_US
dc.identifier.uri http://hdl.handle.net/1773/1990 en_US
dc.description.abstract Recent experimental results show that even brief stimulation with antigen can cause antigenspecic CD8 T-cells to undergo sustained proliferation followed by differentiation into memory cells. These results show that the dynamics of these immune responses are not governed by constant monitoring of antigen levels, but rather that following stimulation immune cells commit to a "program". At present relatively little is known about the program which governs CD8 cell proliferation and differentiation. For example, we do not know whether the program is completely specified by the initial encounter of a T cell with antigen, or whether it subsequently can be modified by the amount of antigen present. Nor do we know whether the entire program for T cell proliferation and differentiation resides within the T cell itself, or whether some component(s) of the program are determined by cells or molecules external to the CD8 cell. In this paper we construct simple mathematical models which incorporate antigen-independent proliferation and differentiation of CD8 cells during acute infections. We use these models to determine what characteristics the program must have in order to be consistent with the existing data on the dynamics of CD8 responses, and in particular to answer the questions posed above. Our results suggest that the program is not completely de ned by the initial encounter of T cell with antigen but may be augmented by exposure to antigen in a brief window shortly after infection; furthermore, parts of the program may reside external to the T-cells. Finally we examine some of the consequences of the program for pathogen host coevolution. en_US
dc.format.extent 285052 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Elsevier Science en_US
dc.subject immunology en_US
dc.subject CD8+ cells en_US
dc.subject partial differential equations en_US
dc.subject program model en_US
dc.title Models of CD8+ Responses: 1. What is the Antigen-independent Proliferation Program en_US
dc.type Article en_US


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