Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens

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Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens

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dc.contributor.author Bergstrom, Carl T. en_US
dc.contributor.author McElhany, Paul en_US
dc.contributor.author Real, Leslie A. en_US
dc.date.accessioned 2004-11-04T04:35:27Z en_US
dc.date.accessioned 2007-06-13T19:58:16Z
dc.date.available 2004-11-04T04:35:27Z en_US
dc.date.available 2007-06-13T19:58:16Z
dc.date.issued 1999-04 en_US
dc.identifier.citation Bergstrom, C. T., P. McElhany, and L. A. Real. 1999. Proceedings of the National Academy of Sciences USA . 96:5095-5100 en_US
dc.identifier.issn 0027-8424 en_US
dc.identifier.uri http://hdl.handle.net/1773/2006 en_US
dc.description.abstract Transmission bottlenecks occur in pathogen populations when only a few individual pathogens are transmitted from one infected host to another in the initiation of a new infection. Transmission bottlenecks can dramatically affect the evolution of virulence in rapidly evolving pathogens such as RNA viruses. Characterizing pathogen diversity with the quasispecies concept, we use analytical and simulation methods to demonstrate that severe bottlenecks are likely to drive down the virulence of a pathogen because of stochastic loss of the most virulent pathotypes, through a process analogous to Muller’s ratchet. We investigate in this process the roles of host population size, duration of within-host viral replication, and transmission bottleneck size. We argue that the patterns of accumulation of deleterious mutation may explain differing levels of virulence in vertically and horizontally transmitted diseases. en_US
dc.format.extent 144983 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher National Academy of the Sciences en_US
dc.title Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens en_US
dc.type Article en_US


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