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dc.contributor.authorBergstrom, Carl T.en_US
dc.contributor.authorMcElhany, Paulen_US
dc.contributor.authorReal, Leslie A.en_US
dc.date.accessioned2004-11-04T04:35:27Zen_US
dc.date.accessioned2007-06-13T19:58:16Z
dc.date.available2004-11-04T04:35:27Zen_US
dc.date.available2007-06-13T19:58:16Z
dc.date.issued1999-04en_US
dc.identifier.citationBergstrom, C. T., P. McElhany, and L. A. Real. 1999. Proceedings of the National Academy of Sciences USA . 96:5095-5100en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/1773/2006en_US
dc.description.abstractTransmission bottlenecks occur in pathogen populations when only a few individual pathogens are transmitted from one infected host to another in the initiation of a new infection. Transmission bottlenecks can dramatically affect the evolution of virulence in rapidly evolving pathogens such as RNA viruses. Characterizing pathogen diversity with the quasispecies concept, we use analytical and simulation methods to demonstrate that severe bottlenecks are likely to drive down the virulence of a pathogen because of stochastic loss of the most virulent pathotypes, through a process analogous to Muller’s ratchet. We investigate in this process the roles of host population size, duration of within-host viral replication, and transmission bottleneck size. We argue that the patterns of accumulation of deleterious mutation may explain differing levels of virulence in vertically and horizontally transmitted diseases.en_US
dc.format.extent144983 bytesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherNational Academy of the Sciencesen_US
dc.titleTransmission bottlenecks as determinants of virulence in rapidly evolving pathogensen_US
dc.typeArticleen_US


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