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dc.contributor.advisorEmerman, Michaelen_US
dc.contributor.authorLim, Efrem S.en_US
dc.date.accessioned2012-08-10T20:22:09Z
dc.date.available2012-08-10T20:22:09Z
dc.date.issued2012-08-10
dc.date.submitted2012en_US
dc.identifier.otherLim_washington_0250E_10050.pdfen_US
dc.identifier.urihttp://hdl.handle.net/1773/20257
dc.descriptionThesis (Ph.D.)--University of Washington, 2012en_US
dc.description.abstractThe immune system has been battling viral infections over the course of millions of years in primate evolution. The constant evolution of hosts and viruses to defeat the other has led to a high stakes genetic arms race. Here I present a detailed study of three antiviral proteins locked in antagonistic viral conflict called Tetherin, Viperin and SAMHD1. Using a combined approach of virology and evolutionary biology, I have reconstructed their evolutionary arms race between primates and lentiviruses, including HIV-1, HIV-2 and related SIVs. The broad themes that emerge from my research are two-fold. First, lentiviruses are able to evolve new functions within existing gene repertoires to counteract rapidly evolving host antiviral genes. Second, hosts escape from viral pressure either by single amino acid changes or by deletions of a `susceptibility domain'. Thus, my thesis research has helped define the rules by which host-virus arms races ensue. Based on my findings, we contend that the host evolutionary framework is a fundamental pillar of antiviral restriction.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.rightsCopyright is held by the individual authors.en_US
dc.subjectAccessory genes; Cross-species transmission; HIV; Host evolution; Restriction factors; Retrovirusen_US
dc.subject.otherVirologyen_US
dc.subject.otherEvolution & developmenten_US
dc.subject.otherMicrobiologyen_US
dc.subject.otherMicrobiologyen_US
dc.titleFundamentals of the Host-Virus Evolutionary Arms Raceen_US
dc.typeThesisen_US
dc.embargo.termsNo embargoen_US


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