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The Interaction of Lingo-1 and Amyloid Precursor Protein

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dc.contributor.advisor Bothwell, Mark A en_US de Laat, Rian C. en_US 2012-09-10T18:30:11Z 2012-09-10T18:30:11Z 2012-09-10 2012 en_US
dc.identifier.other deLaat_washington_0250E_10306.pdf en_US
dc.description Thesis (Ph.D.)--University of Washington, 2012 en_US
dc.description.abstract Proteolytic cleavage of amyloid precursor protein (APP) generates the amyloid β peptide (Aβ), the main component of cortical and subcortical plaques in Alzheimer's disease (AD). APP can be processed at the cell surface or within endosomes after endocytosis, and via an amyloidogenic or non-amyloidogenic pathway. Along the amyloidogenic pathway, APP is first cleaved by β-secretase followed by γ-secretase to produce Aβ. The non-amyloidogenic pathway involves cleavage by α-secretase and then γ-secretase. Aβ generation is thought to occur in a variety of organelles where APP, β- and γ-secretase reside. Proteins that regulate endocytosis and trafficking can thus control the qualitative proteolysis of APP, and consequently may be associated with pathophysiology of AD. One such protein is Lingo-1, which promotes APP trafficking to the lysosome and concomitant degradation, independent of the secretory pathway. In this manner, Lingo-1 may function as a control mechanism for APP levels. en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.rights Copyright is held by the individual authors. en_US
dc.subject Amyloid Precursor Protein; APP; endosome; Lingo; proteolysis en_US
dc.subject.other Neurosciences en_US
dc.subject.other Physiology en_US
dc.subject.other Biology en_US
dc.subject.other Physiology and biophysics en_US
dc.title The Interaction of Lingo-1 and Amyloid Precursor Protein en_US
dc.type Thesis en_US
dc.embargo.terms No embargo en_US

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