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Smear Negative Tuberculosis in HIV-Infected Patients: Treatment Outcomes and Factors Associated with Delay in Initiating Treatment Peru 2005-2010

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dc.contributor.advisor Zunt, Joseph R en_US Saavedra Sevillano, Lilian en_US 2012-09-13T17:29:55Z 2013-09-14T11:05:25Z 2012-09-13 2012 en_US
dc.identifier.other SaavedraSevillano_washington_0250O_10305.pdf en_US
dc.description Thesis (Master's)--University of Washington, 2012 en_US
dc.description.abstract Objectives: The primary aims of this study were to estimate the proportion of SnPTB in HIV co-infected patients, to identify the clinical, demographic, and radiographic factors associated with SnPTB, and to compare TB treatment outcomes and survival rates between patients diagnosed with SnPTB and SpPTB. Methods: A retrospective cohort of TB/HIV co-infected patients who started TB treatment between 2005 and 2010 under the TB control Program at posts, health centers, hospitals, or at one of five reference hospitals providing care for HIV-infected patients under the Ministry of Health system in three regions of the Peruvian Amazon. Results: Of the 332 patients with TB and HIV co-infection, 220 patients were included in this study. 56.8% patients were diagnosed with SnPTB and in the multivariate model, three factors were associated with a diagnosis of SnPTB: concurrent opportunistic infection (OR=4.8, 95%CI: 1.4-16.4), and alveolar infiltrate (OR=7.9, 95%CI: 1.9-31.8) or miliary infiltrate (OR=29.3, 95%CI: 4.3-199.7) on chest radiography. Forty-five percent of patients had an unsuccessful. Treatment at a level II or III health facility (OR=4.8, 95%CI: 2.1-10.8), and a history of addictive habits (OR=5.7, 95%CI: 1.8-18.2) were associated with increased likelihood of unsuccessful TB treatment outcome. Compared to SpPTB, SnPTB was associated with an 85% increased risk of death at one year (HR=1.85, 95%CI: 1.1-3.24), after adjusting for CD4 cell count, completed treatment, age, concurrent opportunistic infection, chronic pre-existing conditions, and use of HAART. The majority of deaths (74%) occurred while receiving TB treatment. Among patients with SnPTB, the median delay between diagnosis and initiation of TB treatment was two days (IQR=0-5). In the multivariate analysis, treatment delay was higher among patients with a history of addictive habits (OR=3.6, 95%CI: 1.1-12.1) and in patients living farther from the health facility. Conclusions: More aggressive TB surveillance and treatment monitoring activities should be routinely performed in smear negative patients. Further studies are needed to develop and evaluate innovative and inexpensive methods to ensure that patients living distant from health facilities or affected by alcohol abuse receive appropriate monitoring and therapy. Key words: smear negative pulmonary tuberculosis, treatment outcome, HIV infection. en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.rights Copyright is held by the individual authors. en_US
dc.subject HIV infection; smear negative pulmonary tuberculosis; treatment outcome en_US
dc.subject.other Public health en_US
dc.subject.other Global Health en_US
dc.title Smear Negative Tuberculosis in HIV-Infected Patients: Treatment Outcomes and Factors Associated with Delay in Initiating Treatment Peru 2005-2010 en_US
dc.type Thesis en_US
dc.embargo.terms Delay release for 1 year -- then make Open Access en_US

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