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Adverse Events Associated with Bevacizumab and Chemotherapy in Older Patients with Metastatic Colorectal Cancer

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dc.contributor.advisor Ramsey, Scott D en_US Shankaran, Veena en_US 2012-09-13T17:35:48Z 2013-09-14T11:05:26Z 2012-09-13 2012 en_US
dc.identifier.other Shankaran_washington_0250O_10328.pdf en_US
dc.description Thesis (Master's)--University of Washington, 2012 en_US
dc.description.abstract <bold>Background</bold>: The safety of bevacizumab in older metastatic colorectal cancer (mCRC) patients is not well understood. The purpose of this analysis was to determine the prevalence of treatment–associated adverse events (AEs), to describe patterns of bevacizumab use in patients with preexisting comorbidities, and to determine incidence of and risk factors for serious adverse events in patients who do and do not receive bevacizumab. <bold>Methods</bold>: Patients age ≥65 were identified from SEER–Medicare and categorized by mCRC diagnosis pre and post–bevacizumab approval (2001–3 vs. 2005–7). Preexisting conditions known to increase risk of bevacizumab– related AEs were identified in the year pre– diagnosis. Factors associated with bevacizumab receipt were identified using logistic regression. Incidence rates for all AEs and specific serious AEs (deep vein thrombosis (DVT), pulmonary embolus (PE), stroke, myocardial infarction (MI), gastrointestinal (GI) hemorrhage and perforation) were determined. A competing risks regression analysis was used to determine risk factors for first AE. <bold>Results</bold>: Of 6,821 total patients, 3,282 (48%) were diagnosed after 2005 and 622 (9%) received first-line bevacizumab. Likelihood of bevacizumab receipt was lower in patients age ≥ 75 (OR 0.41, 95% CI 0.36–0.47), non–whites (OR 0.67, 95% CI 0.55–0.81), patients with higher comorbidity index (OR 0.52, 95% CI 0.44–0.62), and patients with preexisting cerebrovascular disease (0.49, 95% CI 0.33–0.72). Preexising gastrointestinal conditions, by contrast, were associated with an increased likelihood of bevacizumab receipt (OR 2.26, 95% CI 1.96–2.61). Overall AE incidence rate was not increased among patients receiving first–line bevacizumab compared to patients receiving first–line chemotherapy alone (141 AEs vs. 135 AEs / 100,000 person–days (PD)). Incidence rates for specific AEs (DVT/PE, stroke, MI, GI hemorrhage, and perforation) were also similar between patients who did and did not receive first–line bevacizumab. In a competing risks regression, bevacizumab receipt (2005–7) was not associated with an increased risk of first AE compared with receipt of chemotherapy alone (2001–7) when controlling for age, race, comorbidity index, gender, chemotherapy regimen, and preexisting conditions (HR 0.97, 95% CI 0.87–1.08, p=0.55). <bold>Conclusions</bold>: In a population of older mCRC patients, bevacizumab receipt was less likely in patients who were older, non–white, and had preexisting cerebrovascular comorbidities. First–line bevacizumab receipt was not associated with increased overall AE incidence or risk of first AE compared with chemotherapy alone. en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.rights Copyright is held by the individual authors. en_US
dc.subject Drug Safety en_US
dc.subject.other Oncology en_US
dc.subject.other Pharmaceutical sciences en_US
dc.subject.other Medicine en_US
dc.subject.other Pharmaceutics en_US
dc.title Adverse Events Associated with Bevacizumab and Chemotherapy in Older Patients with Metastatic Colorectal Cancer en_US
dc.type Thesis en_US
dc.embargo.terms Restrict to UW for 1 year -- then make Open Access en_US

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