Palladium(II) Catalyzed Intramolecular Hydroamination of 1,3-dienes
Pierson, Justin Michael
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A highly regioselective palladium catalyzed intramolecular hydroamination of substituted 1,3-dienes was achieved to create diverse nitrogen containing heterocycles. Hydroamination of 1,3-dienes goes in high yields, is selective for 1,2 addition and is suitable for a wide variety of nitrogen protect-ing groups. Insight to the mechanism of 1,3-diene hydroamination was accomplished by isolating a crucial palladium allyl complex.
- Chemistry