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dc.contributor.advisorKovacs, Julia Aen_US
dc.contributor.authorCoggins, Michaelen_US
dc.date.accessioned2013-04-17T17:59:11Z
dc.date.available2013-10-15T11:06:15Z
dc.date.issued2013-04-17
dc.date.submitted2012en_US
dc.identifier.otherCoggins_washington_0250E_11267.pdfen_US
dc.identifier.urihttp://hdl.handle.net/1773/22496
dc.descriptionThesis (Ph.D.)--University of Washington, 2012en_US
dc.description.abstractThis dissertation focuses upon the synthesis, characterization, and reactivity of thiolate-ligated manganese complexes. Chapter 1 provides a brief introduction to the importance of manganese ions in biology, as well as the unique properties promoted by thiolate ligands. Chapter 2 discusses the synthesis and characterization of a library of structurally-analogous manganese(II) complexes used for further studies. Chapters 3-5 discuss the reactivity of the complexes discussed in Chapter 2 with various biologically-relevant oxidants, such as dioxygen, superoxide, and peroxides. Finally, Chapter 6 discusses the synthesis, characterization, and reactivity of model complexes for the manganese lipoxygenase metalloenzyme family. The results described throughout this dissertation provide many rare and unique insights into the role played by manganese in biology, as well as how various reaction intermediate species formed from manganese complexes may have relevance to reactions catalyzed in biology.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.rightsCopyright is held by the individual authors.en_US
dc.subject.otherChemistryen_US
dc.subject.otherchemistryen_US
dc.titleSmall Molecule Activation Studies Involving Thiolate-Ligated Manganese(II) Complexes and Biologically-Relevant Oxidantsen_US
dc.typeThesisen_US
dc.embargo.termsRestrict to UW for 6 months -- then make Open Accessen_US


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