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dc.contributor.advisorSeibel, Eric Jen_US
dc.contributor.authorCoe, Ryan Leeen_US
dc.date.accessioned2013-07-25T17:57:31Z
dc.date.available2015-12-14T17:55:48Z
dc.date.issued2013-07-25
dc.date.submitted2013en_US
dc.identifier.otherCoe_washington_0250E_11649.pdfen_US
dc.identifier.urihttp://hdl.handle.net/1773/23761
dc.descriptionThesis (Ph.D.)--University of Washington, 2013en_US
dc.description.abstractLung cancer is the leading cause of cancer related deaths worldwide with 1.37 millions deaths per year. In 2011, Computed Tomography became the first method approved for early detection, however it is hindered by safety concerns due to its use of radiation and it is only capable of detecting masses greater than 2mm in diameter. In an effort to perform early detection before masses are visible, VisionGate Inc. is developing a microscope based on Optical Projection Tomographic Microscopy (OPTM) to detect cancer at the cellular level. OPTM reconstructs three-dimensional images of single cells from projection images acquired from different perspectives around the cell. This dissertation presents a computer simulation that is designed to analyze all aspects of OPTM image formation, such as degree of specimen staining, refractive index matching, and objective scanning. The computer simulation is used in conjunction with experimental methods to refine conclusions and improve system design in a robust methodology. While this work is currently driving improved microscope design, in the long term it will provide a framework to develop quantitative microscopy where pixel values are directly related to cellular optical properties. These improvements will provide improved sensitivity and specificity for early detection and ultimately reduce lung cancer mortality.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.rightsCopyright is held by the individual authors.en_US
dc.subjectComputational Modeling; Finite-Difference Time-Domain Method; Lung Cancer; Microscopy; Mie theoryen_US
dc.subject.otherBiomedical engineeringen_US
dc.subject.otherbioengineeringen_US
dc.titleComputational Modeling of Optical Projection Tomographic Microscopyen_US
dc.typeThesisen_US
dc.embargo.termsDelay release for 2 years -- then make Open Accessen_US


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