ResearchWorks Archive
    • Login
    View Item 
    •   ResearchWorks Home
    • Dissertations and Theses
    • Nutritional sciences
    • View Item
    •   ResearchWorks Home
    • Dissertations and Theses
    • Nutritional sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Metabolism of Plant Lignans by Human Intestinal Bacteria

    Thumbnail
    View/Open
    Yoder_washington_0250O_12268.pdf (5.004Mb)
    Date
    2013-11-14
    Author
    Yoder, Seth Chapman
    Metadata
    Show full item record
    Abstract
    Dietary plant lignans have been implicated in the prevention of several chronic diseases including breast cancer, colon cancer, and cardiovascular disease. Plant lignans can be converted to the physiologically active enterolignans enterodiol and enterolactone by anaerobic bacteria residing in the intestine. Significant interindividual variation has been observed regarding the ability of intestinal bacterial communities to metabolize plant lignans to enterolignans. However, little is known about what characterizes a high enterolignan-producing community from a low enterolignan-producing community. This work presents the development of a platform that can be used to study communities of lignan-converting intestinal bacteria in vitro. Variables that were tested include media type, fecal inoculum concentration, stool processing, and sample headspace. Optimal conditions for enterolignan production and reproducibility consisted of a simple media containing sodium acetate and sodium formate, a total fecal concentration of greater than 1.0%, homogenized slurry processed in a batch, and a headspace-slurry ratio of 3:2.
    URI
    http://hdl.handle.net/1773/24123
    Collections
    • Nutritional sciences [92]

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    @mire NV