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dc.contributor.advisorHeinecke, Jay Wen_US
dc.contributor.authorThomas, Katieen_US
dc.date.accessioned2015-02-24T17:37:50Z
dc.date.submitted2014en_US
dc.identifier.otherThomas_washington_0250E_13901.pdfen_US
dc.identifier.urihttp://hdl.handle.net/1773/27535
dc.descriptionThesis (Ph.D.)--University of Washington, 2014en_US
dc.description.abstractIt has been known for decades that cigarette smoking is associated with atherosclerosis; however, the specific mechanisms for this association remain unclear. High density lipoprotein (HDL) is known to play a key atheroprotective function by removing excess cellular cholesterol, thereby reversing atherosclerotic lesion formation. Here, we investigate whether smoking causes oxidation of HDL proteins, leading to loss of function. We utilized three separate study populations to interrogate HDL function, protein modification, particle size, and protein cargo--each of which provides distinct information about HDL and its potential roles in biological processes. We observed altered HDL function, particle subpopulations, and protein cargo in smokers. Notably, HDL levels of alpha-1 antitrypsin, an acute phase protein, were positively associated with smoking status. These observations have implications for a role of smoking in generating modified forms of HDL that promote atherosclerosis.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.rightsCopyright is held by the individual authors.en_US
dc.subjectcholesterol; HDL; lipoprotein; metabolism; proteomics; smokingen_US
dc.subject.otherMedicineen_US
dc.subject.otherNutritionen_US
dc.subject.otherBiochemistryen_US
dc.subject.othermolecular and cellular biologyen_US
dc.titleThe Impact of Cigarette Smoking on HDL Composition and Functionen_US
dc.typeThesisen_US
dc.embargo.termsRestrict to UW for 1 year -- then make Open Accessen_US
dc.embargo.lift2016-02-24T17:37:50Z


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