Comparative medicine
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Increased Anxiety in Aging Mice is Associated with Cognitive Decline and Decreased Wheel- running
This research project explores the relationship between anxiety and aging in mice, focusing on various physiological and behavioral parameters. The study used open field tests, cognitive function assessments, grip strength ... -
The Actin Regulatory Protein Hem1 Regulates T cell Homeostasis and Cytokine Production in a T Cell Specific Manner
Hematopoietic Protein-1 (Hem1) is a hematopoietic cell specific component of the actin regulatory WAVE complex, which is activated downstream of multiple immune receptors and a mediator of f-actin polymerization. Mutations ... -
Role of macrophage-derived versican in the innate immune response to LPS
Versican, a chondroitin sulfate proteoglycan (CSPG), is an integral component of the extracellular matrix (ECM) necessary for embryonic development, but thereafter is expressed in very low levels in healthy adult lungs. ... -
A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways
Aging is a primary risk factor for cognitive dysfunction and exacerbates multiple biological processes in the brain, including but not limited to nutrient sensing dysregulation, insulin sensing dysfunction and histone ... -
Fibroblast p38-MAPK signaling modulates cardiac function and phenotype in mouse models of inherited dilated and hypertrophic cardiomyopathy
Inherited cardiomyopathies are common causes of heart failure in the general population that present with two main clinical phenotypes: dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). Little is known ... -
Murine norovirus inhibits B cell development in bone marrow, but does not impair antibody production in Stat1-/- mice
Murine norovirus (MNV) is used as a model system to study human noroviruses, can infect macrophages/monocytes, neutrophils, dendritic, intestinal epithelial, T and B cells, and is highly prevalent in laboratory mice. We ... -
Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment
Sleep deprivation is a universal issue that affects individuals in differing ways. While some individuals experience a deficit in daily performance, others experience resiliency as they can maintain high levels of physical ... -
Conditional Disruption of Hem-1 Results in Impaired B Cell Development and Aberrant Antibody Production
Hematopoietic protein-1 is a hematopoietic cell specific member of the actin-regulatory WAVE complex, which acts downstream of multiple immune receptors to stimulate F-actin polymerization. Loss-of-function mutations in ... -
Conditional Disruption of Hem-1 Results in Impaired Development of Alveolar Macrophages, Pulmonary Alveolar Proteinosis, and Increased Susceptibility to Influenza Virus Infection
Hematopoietic protein-1 is a hematopoietic cell specific member of the actin-regulatory WAVE (Wiskott-Aldrich syndrome verprolin-homologous protein) complex 2, which acts downstream of many immune receptors and activated ... -
Nutritional Gel Supplementation Reduces Weight Loss and Mortality in Mice Infected with Influenza A/PR/8/34 Virus
Influenza virus A (IAV) places a high-burden on public health. Studies of IAV commonly use mice to model the response of the immune system in vivo. Complications of IAV studies include anorexia and dehydration with subsequent ... -
Kinetics of the Chronic Stress Response to Stocking Density and Impacts on Infectious Hematopoietic Necrosis Virus Mortality in Rainbow Trout
The goal of this study was to examine the effect of stocking density on the stress response and susceptibility to infectious hematopoietic necrosis virus (IHNV) induced mortality in fingerling rainbow trout (Oncorhynchus ... -
A novel BOX maze learning paradigm measures sleep-induced cognitive impairment
Sleep deprivation-induced cognitive impairment is a major health concern in developed countries and is an age-related risk factor for neurological conditions such as dementia associated with Alzheimer’s disease. There is ... -
Hematopoietic Stem Cell-Derived Chimeric Antigen Receptor Expressing Cells Traffic to HIV Reservoir Sites in SHIV-Infected Non-Human Primates
The successful treatment of 2 HIV+ individuals with allogeneic stem cell transplantations has garnered much interest in its utility as a therapy for HIV. However, there are significant limitations that prevent allogeneic ... -
Evidence for Minimal Cardiogenic Potential of Sca-1 Positive Cells in the Adult Mouse Heart
Despite modern pharmacotherapy, heart failure remains a major medical burden. The heart has a limited regenerative capacity, and bolstering regeneration might represent new therapeutic approaches for heart failure patients. ... -
Loss of Fnip1 Results in Renal Cyst Formation and Synergizes with TSC1 Loss to Promote mTORC1 Activation
Birt-Hogg-Dube’ Syndrome (BHDS) is a rare genetic disorder in humans characterized by increased risk for renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, and cytoplasmic adapter ... -
Mechanisms of B and T lymphocyte accumulation in tumor-draining lymph nodes
Tumor-draining lymph nodes (TDLNs) often enlarge in human cancer patients and in murine tumor models, due to lymphocyte accumulation and lymphatic sinus growth. B lymphocytes within TDLNs can drive lymph node hypertrophy ...
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