Browsing Comparative medicine by Author "Iritani, Brian M"
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Conditional Disruption of Hem-1 Results in Impaired B Cell Development and Aberrant Antibody Production
Avalos, Alan VinicioHematopoietic protein-1 is a hematopoietic cell specific member of the actin-regulatory WAVE complex, which acts downstream of multiple immune receptors to stimulate F-actin polymerization. Loss-of-function mutations in ... -
Conditional Disruption of Hem-1 Results in Impaired Development of Alveolar Macrophages, Pulmonary Alveolar Proteinosis, and Increased Susceptibility to Influenza Virus Infection
Suwankitwat, NutthakarnHematopoietic protein-1 is a hematopoietic cell specific member of the actin-regulatory WAVE (Wiskott-Aldrich syndrome verprolin-homologous protein) complex 2, which acts downstream of many immune receptors and activated ... -
Loss of Fnip1 Results in Renal Cyst Formation and Synergizes with TSC1 Loss to Promote mTORC1 Activation
Centini, Ryan MichaelBirt-Hogg-Dube’ Syndrome (BHDS) is a rare genetic disorder in humans characterized by increased risk for renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, and cytoplasmic adapter ...