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Loss of Fnip1 Results in Renal Cyst Formation and Synergizes with TSC1 Loss to Promote mTORC1 Activation
Birt-Hogg-Dube’ Syndrome (BHDS) is a rare genetic disorder in humans characterized by increased risk for renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, and cytoplasmic adapter protein which binds to two other proteins called FNIP1 and FNIP2 (Folliculin interacting proteins-1 and -2) ...