Browsing Psychiatry and Behavioral Sciences, Department of by Issue Date
Now showing items 1-20 of 38
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Cardiovascular and Neuroendocrine Responses to Extended Laboratory Challenge
(American Psychosomatic Society, 1993)The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both ... -
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat
(American Psychological Society, 1999)Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ... -
Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates
(Journal of Neuroscience, 1999-03-15)Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ... -
Low Plasma Leptin Levels Contribute to Diabetic Hyperphagia in Rats
(Diabetes, 1999-06)The adipocyte hormone leptin reduces food intake in normal animals. During uncontrolled type 1 diabetes, plasma leptin levels fall, whereas food intake increases. To test the hypothesis that low leptin levels contribute ... -
Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose
(Arch.Gen.Psychiatry, 1999-12)Background: Increasing plasma glucose levels improves memory in patients with Alzheimer disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, raising the question of whether memory ... -
Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat
(Endocrinology, 2000)Pineal melatonin secretion declines with aging, whereas visceral fat, plasma insulin, and plasma leptin tend to increase. We have previously demonstrated that daily melatonin administration at middle age suppressed male ... -
Hypothalamic Melanin-Concentrating Hormone and Estrogen- Induced Weight Loss
(Journal of Neuroscience, 2000-11-15)Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ... -
Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study
(The Journal of Clinical Endocrinology & Metabolism, 2001)We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ... -
Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues
(Investigative Ophthalmology & Visual Science,, 2001-07)PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ... -
Acute Modulation of Aged Human Memory by Pharmacological Manipulation of Glucocorticoids
(The Endocrine Society, 2002)In a previous longitudinal study of basal cortisol levels and cognitive function in humans, we showed that elderly humans with 4- to 7-yr cumulative exposure to high levels of cortisol present memory impairments, compared ... -
Prediction of chronic disability in work-related musculoskeletal disorders: a prospective, population-based study
(2004)Background: Disability associated with work-related musculoskeletal disorders is an increasingly serious societal problem. Although most injured workers return quickly to work, a substantial number do not. The costs of ... -
Chronic pain self-management for older adults: a randomized controlled trial [ISRCTN11899548]
(2004)Background: Chronic pain is a common and frequently disabling problem in older adults. Clinical guidelines emphasize the need to use multimodal therapies to manage persistent pain in this population. Pain self-management ... -
Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis
(Am J Physiol Endocrinol Metab, 2004-08)Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab 287: E1107–E1113, 2004. First published August 10, 2004; ... -
A descriptive study of older adults with persistent pain: Use and perceived effectiveness of pain management strategies [ISRCTN11899548]
(2005)Background: Persistent pain is a common, often debilitating, problem in older adults; however, few studies have focused on the experiences of older adults in managing their pain. The objective of this study was to describe ... -
parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism
(2005)Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to lateonset disease. This dosage pattern suggests ... -
Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet- Induced Obesity in Rats
(Endocrinology, 2005-12)Leptin gains access to the central nervous system where it influences activity of neuronal networks involved in ingestive behavior, neuroendocrine activity, and metabolism. In particular, the brain melanocortin (MC) ... -
Using relationship styles based on attachment theory to improve understanding of specialty choice in medicine
(2006)Background: Patient-provider relationships in primary care are characterized by greater continuity and depth than in non-primary care specialties. We hypothesized that relationship styles of medical students based on ... -
Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during ‘‘abstinence’’
(Alcohol, 2006-04)We have reported that repetitive daily ethanol consumption increased anxiety-like behavior in rats 4 weeks after ethanol consumption had ceased, consistent with the persistently increased anxiety exhibited by abstinent ... -
Antecedent Hindbrain Glucoprivation Does Not Impair the Counterregulatory Response to Hypoglycemia
(Diabetes, 2007-01)Recurrent hypoglycemia impairs hormonal counterregulatory responses (CRRs) to further bouts of hypoglycemia. The hypothalamus and hindbrain are both critical for sensing hypoglycemia and triggering CRRs. Hypothalamic ...