ResearchWorks Archive

Browsing Psychiatry and Behavioral Sciences, Department of by Author "Wilkinson, Charles W."

Browsing Psychiatry and Behavioral Sciences, Department of by Author "Wilkinson, Charles W."

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  • Al-Noori, Salwa; Sanders, Nicole M.; Wilkinson, Charles W.; Figlewicz, Dianne P.; Taborsky Jr., Gerald J. (Brain Res, 2008-02-15)
    The posterior paraventricular nucleus of the thalamus (THPVP) has been identified as a forebrain region that modulates the central nervous system (CNS) response to recurrent experiences of stressors. The THPVP is activated ...
  • Radant, Allen D.; Dobie, Dorcas J.; Peskind, Elaine R.; Murburg, M. Michele; Petrie, Eric C.; Kanter, Evan D.; Raskind, Murray A.; Wilkinson, Charles W. (Frontiers in Behavioral Neuroscience, 2009-10-30)
    Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to ...
  • Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; McTiernan, Anne; Cholerton, Brenna A.; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (JOURNAL OF ALZHEIMER'S DISEASE, 2010)
    Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise ...
  • Sanders, Nicole M.; Taborsky Jr., Gerald J; Wilkinson, Charles W.; Daumen, Wendi; Figlewicz, Dianne P. (Diabetes, 2007-01)
    Recurrent hypoglycemia impairs hormonal counterregulatory responses (CRRs) to further bouts of hypoglycemia. The hypothalamus and hindbrain are both critical for sensing hypoglycemia and triggering CRRs. Hypothalamic ...
  • McCann, Barbara S.; Carter, James; Vaughan, Mary; Raskind, Murray; Wilkinson, Charles W.; Veith, Richard C. (American Psychosomatic Society, 1993)
    The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both ...
  • Tyrka, Audrey R.; Wier, Lauren; Price, Lawrence H; Ross, Nicole; Anderson, George M.; Wilkinson, Charles W.; Carpenter, Linda L. (Biol. Psychiatry, 2008-06-15)
    Background—Several decades of research link childhood parental loss with risk for major depression and other forms of psychopathology. A large body of preclinical work on maternal separation and some recent studies of ...
  • Rasmussen, Dennis D.; Wilkinson, Charles W.; Raskind, Murray A. (Alcohol, 2006-04)
    We have reported that repetitive daily ethanol consumption increased anxiety-like behavior in rats 4 weeks after ethanol consumption had ceased, consistent with the persistently increased anxiety exhibited by abstinent ...
  • Wilkinson, Charles W. (The Endocrine Society, 2008)
  • Carpenter, Linda L.; Carvalho, John P.; Tyrka, Audrey R.; Wier, Lauren M.; Mello, Andrea F.; Anderson, George M.; Wilkinson, Charles W.; Price, Lawrence H. (Biol. Psychiatry, 2007-11-15)
    Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ...
  • Peretz, Alon; Sullivan, Jeffrey H.; Leotta, Daniel F.; Trenga, Carol A.; Sands, Fiona F.; Allen, Jason; Carlsten, Chris; Wilkinson, Charles W.; Gill, Edward A.; Kaufman, Joel D. (Environmental Health Perspectives, 2008-07-07)
    BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel ...
  • Leverenz, James P.; Wilkinson, Charles W.; Wamble, Molly; Corbin, Shannon; Grabber, Jo Ellen; Raskind, Murray A.; Raskind, Elaine R. (Journal of Neuroscience, 1999-03-15)
    Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ...
  • Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; Mctiernan, Anne; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Cholerton, Brenna A.; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (Archives of Neurology, 2010-01)
    Objectives—To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor ...
  • Crtaft, Suzanne; Asthana, Sanjay; Newcomer, John W.; Wilkinson, Charles W.; Tio Matos, Iris; Baker, Laura D.; Cherrier, Monique; Lofgreen, Cassin; Latendresse, Shawn; Petrova, Andreana; Plymate, Stephen; Raskind, Murray; Grimwood, Karla; Veith, Richard C. (Arch.Gen.Psychiatry, 1999-12)
    Background: Increasing plasma glucose levels improves memory in patients with Alzheimer disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, raising the question of whether memory ...
  • Clark, Abbot F.; Steely, Thomas; Dickerson Jr., Jaime E.; English-Wright, Sherry; Stropki, Karen; McCartney, Mitchell D.; Jaconson, Nasreen; Shepard, Allan R.; Clark, John I.; Matsushima, Hiroyuki; Peskind, Elaine R.; Leverenz, James B.; Wilkinson, Charles W.; Swiderski, Ruth E.; Fingert, John H.; Sheffield, Val C.; Stone, Edwin M. (Investigative Ophthalmology & Visual Science,, 2001-07)
    PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ...
  • Wilkinson, Charles W.; Pagulayan, Kathleen F.; Petrie, Eric C.; Mayer, Cynthia L.; Colasurdo, Elizabeth A.; Shofer, Jane B.; Hart, Kim L.; Hoff, David; Tarabochia, Matthew A.; Peskind, Elaine R. (Frontiers in Neurology, 2012-02-07)
    Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ...
  • Wilkinson, Charles W.; Petrie, Eric C.; Murray, Sharon R.; Colasudro, Elizabeth A.; Raskind, Murray R.; Peskind, Elaine R. (The Journal of Clinical Endocrinology & Metabolism, 2001)
    We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ...
  • Mystkowski, Paul; Seely, Randy J.; Hahn, Tina M.; Baskin, Denis G.; Havel, Peter J.; Matsumoto, Alvin M.; Wilkinson, Charles W.; Peacock-Kinzig, Kimberly; Blake, Kathleen A.; Schwartz, Michael W. (Journal of Neuroscience, 2000-11-15)
    Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ...
  • Van Dijk, Gertjan; Seely, Randy J.; Thiele, Todd E.; Friedman, Mark I.; Ji, Hong; Wilkinson, Charles W.; Burn, Paul; Campfield, Arthur; Tenenbauim, Renata; Raskin, Denis G.; Woods, Stephen C. (American Psychological Society, 1999)
    Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ...
  • Al-Noori, Salwa; Sanders, Nicole M.; Taborsky, Gerald J.; Wilkinson, Charles W.; Zavosh, Aryana; West, Connie; Sanders, Colleen M.; Figlewicz, Dianne P. (American Journal of Physiology, 2008-08-27)
    A limiting factor to the clinical management of diabetes is iatrogenic hypoglycemia. With multiple hypoglycemic episodes, the collective neuroendocrine response that restores euglycemia is impaired. In our animal model ...
  • van Dijk, Gertjan; de Vries, Koert; Nyakas, Csaba; Buwalde, Bauke; Adage, Tiziana; Kuipers, Folkert; Kas, Martien J.H.; Adan, Roger A.H.; Wilkinson, Charles W.; Thiele, Todd E.; Scheurink, Anton J.W. (Endocrinology, 2005-12)
    Leptin gains access to the central nervous system where it influences activity of neuronal networks involved in ingestive behavior, neuroendocrine activity, and metabolism. In particular, the brain melanocortin (MC) ...

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