Now showing items 21-36 of 36

    • Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment 

      Carpenter, Linda L.; Carvalho, John P.; Tyrka, Audrey R.; Wier, Lauren M.; Mello, Andrea F.; Anderson, George M.; Wilkinson, Charles W.; Price, Lawrence H. (Biol. Psychiatry, 2007-11-15)
      Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ...
    • Circadian Clocks: Showtime for the Adrenal Cortex 

      Wilkinson, Charles W. (The Endocrine Society, 2008)
    • Ultra-brief intervention for problem drinkers: research protocol 

      Cunningham, John A.; Neighbors, Clayton; Wild, Cameron; Humphreys, Keith (2008)
      Background: Helping the large number of problem drinkers who will never seek treatment is a challenging issue. Public health initiatives employing educational materials or mass media campaigns have met with mixed success. ...
    • Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia 

      Al-Noori, Salwa; Sanders, Nicole M.; Wilkinson, Charles W.; Figlewicz, Dianne P.; Taborsky Jr., Gerald J. (Brain Res, 2008-02-15)
      The posterior paraventricular nucleus of the thalamus (THPVP) has been identified as a forebrain region that modulates the central nervous system (CNS) response to recurrent experiences of stressors. The THPVP is activated ...
    • Cortisol and ACTH Responses to the Dex/CRH Test: Influence of Temperament 

      Tyrka, Audrey M.; Wier, Lauren M.; Price, Lawrence H.; Rikhye, Kobita; Ross, Nicole S.; Anderson, George M.; Carpenter, Linda L.; Wilkinson, Charles M. (Horm. Behav., 2008-04)
      Temperament and personality traits such as neuroticism and behavioral inhibition are prospective predictors of the onset of depression and anxiety disorders. Exposure to stress is also linked to the development of these ...
    • The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia 

      Sanders, Nicole M.; Wilkinson, Charles W.; Taborsky Jr., Gerald J.; Al-Noori, Salwa; Daumen, Wendi; Zavosh, Aryana; Figlewicz, Dianne P. (Am J Physiol Endocrinol Metab., 2008-05)
      Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate ...
    • Childhood Parental Loss and Adult Hypothalamic-Pituitary- Adrenal Function 

      Tyrka, Audrey R.; Wier, Lauren; Price, Lawrence H; Ross, Nicole; Anderson, George M.; Wilkinson, Charles W.; Carpenter, Linda L. (Biol. Psychiatry, 2008-06-15)
      Background—Several decades of research link childhood parental loss with risk for major depression and other forms of psychopathology. A large body of preclinical work on maternal separation and some recent studies of ...
    • Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo 

      Peretz, Alon; Sullivan, Jeffrey H.; Leotta, Daniel F.; Trenga, Carol A.; Sands, Fiona F.; Allen, Jason; Carlsten, Chris; Wilkinson, Charles W.; Gill, Edward A.; Kaufman, Joel D. (Environmental Health Perspectives, 2008-07-07)
      BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel ...
    • Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin 

      Al-Noori, Salwa; Sanders, Nicole M.; Taborsky, Gerald J.; Wilkinson, Charles W.; Zavosh, Aryana; West, Connie; Sanders, Colleen M.; Figlewicz, Dianne P. (American Journal of Physiology, 2008-08-27)
      A limiting factor to the clinical management of diabetes is iatrogenic hypoglycemia. With multiple hypoglycemic episodes, the collective neuroendocrine response that restores euglycemia is impaired. In our animal model ...
    • Adrenocortical responsiveness to adrenocorticotropin: StAR is ascendant. 

      Wilkinson, Charles (Endocrinology, 2009-06)
    • Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder 

      Radant, Allen D.; Dobie, Dorcas J.; Peskind, Elaine R.; Murburg, M. Michele; Petrie, Eric C.; Kanter, Evan D.; Raskind, Murray A.; Wilkinson, Charles W. (Frontiers in Behavioral Neuroscience, 2009-10-30)
      Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to ...
    • Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer’s Disease 

      Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; McTiernan, Anne; Cholerton, Brenna A.; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (JOURNAL OF ALZHEIMER'S DISEASE, 2010)
      Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise ...
    • Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial 

      Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; Mctiernan, Anne; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Cholerton, Brenna A.; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (Archives of Neurology, 2010-01)
      Objectives—To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor ...
    • High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury 

      Wilkinson, Charles W.; Pagulayan, Kathleen F.; Petrie, Eric C.; Mayer, Cynthia L.; Colasurdo, Elizabeth A.; Shofer, Jane B.; Hart, Kim L.; Hoff, David; Tarabochia, Matthew A.; Peskind, Elaine R. (Frontiers in Neurology, 2012-02-07)
      Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ...
    • Hypopituitarism caused by blast-related mTBI may result in PTSD-like symptoms 

      Schultz, Jaclyn S.; Burges, Debra E.; Shofer, Jane B; Wilkinson, Charles W. (Society for Behavioral Neuroendocrinology, 2017-06-11)
      Recent studies in civilian populations have found the prevalence of hypopituitarism as a result of head injuries from all causes to be between 25 and 50%. However, the neuroendocrine effects of concussion, or mild traumatic ...
    • DOPA Decarboxylase Modulates Tau Toxicity 

      Kow, Rebecca L.; Sikkema, Carl; Wheeler, Jeanna M.; Wilkinson, Charles W.; Kraemer, Brian C. (Elsevier, 2018-03-01)
      BACKGROUND: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple ...