Now showing items 10-29 of 36

    • Chronic pain self-management for older adults: a randomized controlled trial [ISRCTN11899548] 

      Ersek, Mary; Turner, Judith A.; Cain, Kevin C.; Kemp, Carol A. (2004)
      Background: Chronic pain is a common and frequently disabling problem in older adults. Clinical guidelines emphasize the need to use multimodal therapies to manage persistent pain in this population. Pain self-management ...
    • Circadian Clocks: Showtime for the Adrenal Cortex 

      Wilkinson, Charles W. (The Endocrine Society, 2008)
    • Cortisol and ACTH Responses to the Dex/CRH Test: Influence of Temperament 

      Tyrka, Audrey M.; Wier, Lauren M.; Price, Lawrence H.; Rikhye, Kobita; Ross, Nicole S.; Anderson, George M.; Carpenter, Linda L.; Wilkinson, Charles M. (Horm. Behav., 2008-04)
      Temperament and personality traits such as neuroticism and behavioral inhibition are prospective predictors of the onset of depression and anxiety disorders. Exposure to stress is also linked to the development of these ...
    • Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin , and plasma insulin to youthful levels 

      Rasmussen, Dennis D; Boldt, Brian M.; Wilkinson, Charles M.; Yellon, Steven M.; Matsumoto, Alvin M. (Endocrinology, 1999)
    • Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat 

      Wolden-Hanson, T; Mitton, D.R.; McCants, R.L.; Yellon, S.R.; Wilkinson, C.W.; Matsumoto, A.M.; Rasmusson, D.D. (Endocrinology, 2000)
      Pineal melatonin secretion declines with aging, whereas visceral fat, plasma insulin, and plasma leptin tend to increase. We have previously demonstrated that daily melatonin administration at middle age suppressed male ...
    • Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment 

      Carpenter, Linda L.; Carvalho, John P.; Tyrka, Audrey R.; Wier, Lauren M.; Mello, Andrea F.; Anderson, George M.; Wilkinson, Charles W.; Price, Lawrence H. (Biol. Psychiatry, 2007-11-15)
      Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ...
    • A descriptive study of older adults with persistent pain: Use and perceived effectiveness of pain management strategies [ISRCTN11899548] 

      Kemp, Carol A.; Ersek, Mary; Turner, Judith A. (2005)
      Background: Persistent pain is a common, often debilitating, problem in older adults; however, few studies have focused on the experiences of older adults in managing their pain. The objective of this study was to describe ...
    • Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo 

      Peretz, Alon; Sullivan, Jeffrey H.; Leotta, Daniel F.; Trenga, Carol A.; Sands, Fiona F.; Allen, Jason; Carlsten, Chris; Wilkinson, Charles W.; Gill, Edward A.; Kaufman, Joel D. (Environmental Health Perspectives, 2008-07-07)
      BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel ...
    • DOPA Decarboxylase Modulates Tau Toxicity 

      Kow, Rebecca L.; Sikkema, Carl; Wheeler, Jeanna M.; Wilkinson, Charles W.; Kraemer, Brian C. (Elsevier, 2018-03-01)
      BACKGROUND: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple ...
    • Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates 

      Leverenz, James P.; Wilkinson, Charles W.; Wamble, Molly; Corbin, Shannon; Grabber, Jo Ellen; Raskind, Murray A.; Raskind, Elaine R. (Journal of Neuroscience, 1999-03-15)
      Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ...
    • Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial 

      Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; Mctiernan, Anne; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Cholerton, Brenna A.; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (Archives of Neurology, 2010-01)
      Objectives—To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor ...
    • Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose 

      Crtaft, Suzanne; Asthana, Sanjay; Newcomer, John W.; Wilkinson, Charles W.; Tio Matos, Iris; Baker, Laura D.; Cherrier, Monique; Lofgreen, Cassin; Latendresse, Shawn; Petrova, Andreana; Plymate, Stephen; Raskind, Murray; Grimwood, Karla; Veith, Richard C. (Arch.Gen.Psychiatry, 1999-12)
      Background: Increasing plasma glucose levels improves memory in patients with Alzheimer disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, raising the question of whether memory ...
    • Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues 

      Clark, Abbot F.; Steely, Thomas; Dickerson Jr., Jaime E.; English-Wright, Sherry; Stropki, Karen; McCartney, Mitchell D.; Jaconson, Nasreen; Shepard, Allan R.; Clark, John I.; Matsushima, Hiroyuki; Peskind, Elaine R.; Leverenz, James B.; Wilkinson, Charles W.; Swiderski, Ruth E.; Fingert, John H.; Sheffield, Val C.; Stone, Edwin M. (Investigative Ophthalmology & Visual Science,, 2001-07)
      PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ...
    • High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury 

      Wilkinson, Charles W.; Pagulayan, Kathleen F.; Petrie, Eric C.; Mayer, Cynthia L.; Colasurdo, Elizabeth A.; Shofer, Jane B.; Hart, Kim L.; Hoff, David; Tarabochia, Matthew A.; Peskind, Elaine R. (Frontiers in Neurology, 2012-02-07)
      Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ...
    • Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study 

      Wilkinson, Charles W.; Petrie, Eric C.; Murray, Sharon R.; Colasudro, Elizabeth A.; Raskind, Murray R.; Peskind, Elaine R. (The Journal of Clinical Endocrinology & Metabolism, 2001)
      We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ...
    • Hypopituitarism caused by blast-related mTBI may result in PTSD-like symptoms 

      Schultz, Jaclyn S.; Burges, Debra E.; Shofer, Jane B; Wilkinson, Charles W. (Society for Behavioral Neuroendocrinology, 2017-06-11)
      Recent studies in civilian populations have found the prevalence of hypopituitarism as a result of head injuries from all causes to be between 25 and 50%. However, the neuroendocrine effects of concussion, or mild traumatic ...
    • Hypothalamic Melanin-Concentrating Hormone and Estrogen- Induced Weight Loss 

      Mystkowski, Paul; Seely, Randy J.; Hahn, Tina M.; Baskin, Denis G.; Havel, Peter J.; Matsumoto, Alvin M.; Wilkinson, Charles W.; Peacock-Kinzig, Kimberly; Blake, Kathleen A.; Schwartz, Michael W. (Journal of Neuroscience, 2000-11-15)
      Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ...
    • Low Plasma Leptin Levels Contribute to Diabetic Hyperphagia in Rats 

      Sindelar, Dana K.; Havel, Peter J.; Seeley, Randy J.; Wilkinson, Charlew W.; Woods, Stephen C.; Schwartz, Michael W. (Diabetes, 1999-06)
      The adipocyte hormone leptin reduces food intake in normal animals. During uncontrolled type 1 diabetes, plasma leptin levels fall, whereas food intake increases. To test the hypothesis that low leptin levels contribute ...
    • Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat 

      Van Dijk, Gertjan; Seely, Randy J.; Thiele, Todd E.; Friedman, Mark I.; Ji, Hong; Wilkinson, Charles W.; Burn, Paul; Campfield, Arthur; Tenenbauim, Renata; Raskin, Denis G.; Woods, Stephen C. (American Psychological Society, 1999)
      Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ...
    • parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism 

      Poorkaj, Parvoneh; Moses, Lina; Montimurro, Jennifer S.; Nutt, John G.; Schellenberg, Gerard D.; Payami, Haydeh (2005)
      Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to lateonset disease. This dosage pattern suggests ...