Now showing items 18-34 of 34

    • Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates 

      Leverenz, James P.; Wilkinson, Charles W.; Wamble, Molly; Corbin, Shannon; Grabber, Jo Ellen; Raskind, Murray A.; Raskind, Elaine R. (Journal of Neuroscience, 1999-03-15)
      Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ...
    • Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial 

      Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; Mctiernan, Anne; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Cholerton, Brenna A.; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (Archives of Neurology, 2010-01)
      Objectives—To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor ...
    • Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose 

      Crtaft, Suzanne; Asthana, Sanjay; Newcomer, John W.; Wilkinson, Charles W.; Tio Matos, Iris; Baker, Laura D.; Cherrier, Monique; Lofgreen, Cassin; Latendresse, Shawn; Petrova, Andreana; Plymate, Stephen; Raskind, Murray; Grimwood, Karla; Veith, Richard C. (Arch.Gen.Psychiatry, 1999-12)
      Background: Increasing plasma glucose levels improves memory in patients with Alzheimer disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, raising the question of whether memory ...
    • Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues 

      Clark, Abbot F.; Steely, Thomas; Dickerson Jr., Jaime E.; English-Wright, Sherry; Stropki, Karen; McCartney, Mitchell D.; Jaconson, Nasreen; Shepard, Allan R.; Clark, John I.; Matsushima, Hiroyuki; Peskind, Elaine R.; Leverenz, James B.; Wilkinson, Charles W.; Swiderski, Ruth E.; Fingert, John H.; Sheffield, Val C.; Stone, Edwin M. (Investigative Ophthalmology & Visual Science,, 2001-07)
      PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ...
    • High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury 

      Wilkinson, Charles W.; Pagulayan, Kathleen F.; Petrie, Eric C.; Mayer, Cynthia L.; Colasurdo, Elizabeth A.; Shofer, Jane B.; Hart, Kim L.; Hoff, David; Tarabochia, Matthew A.; Peskind, Elaine R. (Frontiers in Neurology, 2012-02-07)
      Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ...
    • Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study 

      Wilkinson, Charles W.; Petrie, Eric C.; Murray, Sharon R.; Colasudro, Elizabeth A.; Raskind, Murray R.; Peskind, Elaine R. (The Journal of Clinical Endocrinology & Metabolism, 2001)
      We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ...
    • Hypothalamic Melanin-Concentrating Hormone and Estrogen- Induced Weight Loss 

      Mystkowski, Paul; Seely, Randy J.; Hahn, Tina M.; Baskin, Denis G.; Havel, Peter J.; Matsumoto, Alvin M.; Wilkinson, Charles W.; Peacock-Kinzig, Kimberly; Blake, Kathleen A.; Schwartz, Michael W. (Journal of Neuroscience, 2000-11-15)
      Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ...
    • Low Plasma Leptin Levels Contribute to Diabetic Hyperphagia in Rats 

      Sindelar, Dana K.; Havel, Peter J.; Seeley, Randy J.; Wilkinson, Charlew W.; Woods, Stephen C.; Schwartz, Michael W. (Diabetes, 1999-06)
      The adipocyte hormone leptin reduces food intake in normal animals. During uncontrolled type 1 diabetes, plasma leptin levels fall, whereas food intake increases. To test the hypothesis that low leptin levels contribute ...
    • Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat 

      Van Dijk, Gertjan; Seely, Randy J.; Thiele, Todd E.; Friedman, Mark I.; Ji, Hong; Wilkinson, Charles W.; Burn, Paul; Campfield, Arthur; Tenenbauim, Renata; Raskin, Denis G.; Woods, Stephen C. (American Psychological Society, 1999)
      Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ...
    • parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism 

      Poorkaj, Parvoneh; Moses, Lina; Montimurro, Jennifer S.; Nutt, John G.; Schellenberg, Gerard D.; Payami, Haydeh (2005)
      Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to lateonset disease. This dosage pattern suggests ...
    • Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis 

      Wisse, Brent E.; Ogimoto, Kayoko; Morton, Gregory J.; Wilkinson, Charlew W.; Frayo, R.Scott; Cummings, David E.; Schwartz, Michael W. (Am J Physiol Endocrinol Metab, 2004-08)
      Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab 287: E1107–E1113, 2004. First published August 10, 2004; ...
    • Prediction of chronic disability in work-related musculoskeletal disorders: a prospective, population-based study 

      Turner, Judith A.; Franklin, Gary; Fulton-Kehoe, Deborah; Egan, Kathleen; Wickizer, Thomas M.; Lymp, James F.; Sheppard, Lianne; Kaufman, Joel D. (2004)
      Background: Disability associated with work-related musculoskeletal disorders is an increasingly serious societal problem. Although most injured workers return quickly to work, a substantial number do not. The costs of ...
    • Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin 

      Al-Noori, Salwa; Sanders, Nicole M.; Taborsky, Gerald J.; Wilkinson, Charles W.; Zavosh, Aryana; West, Connie; Sanders, Colleen M.; Figlewicz, Dianne P. (American Journal of Physiology, 2008-08-27)
      A limiting factor to the clinical management of diabetes is iatrogenic hypoglycemia. With multiple hypoglycemic episodes, the collective neuroendocrine response that restores euglycemia is impaired. In our animal model ...
    • Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet- Induced Obesity in Rats 

      van Dijk, Gertjan; de Vries, Koert; Nyakas, Csaba; Buwalde, Bauke; Adage, Tiziana; Kuipers, Folkert; Kas, Martien J.H.; Adan, Roger A.H.; Wilkinson, Charles W.; Thiele, Todd E.; Scheurink, Anton J.W. (Endocrinology, 2005-12)
      Leptin gains access to the central nervous system where it influences activity of neuronal networks involved in ingestive behavior, neuroendocrine activity, and metabolism. In particular, the brain melanocortin (MC) ...
    • The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia 

      Sanders, Nicole M.; Wilkinson, Charles W.; Taborsky Jr., Gerald J.; Al-Noori, Salwa; Daumen, Wendi; Zavosh, Aryana; Figlewicz, Dianne P. (Am J Physiol Endocrinol Metab., 2008-05)
      Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate ...
    • Ultra-brief intervention for problem drinkers: research protocol 

      Cunningham, John A.; Neighbors, Clayton; Wild, Cameron; Humphreys, Keith (2008)
      Background: Helping the large number of problem drinkers who will never seek treatment is a challenging issue. Public health initiatives employing educational materials or mass media campaigns have met with mixed success. ...
    • Using relationship styles based on attachment theory to improve understanding of specialty choice in medicine 

      Ciechanowski, Paul S.; Worley, Linda LM; Russo, Joan E.; Katon, Wayne J. (2006)
      Background: Patient-provider relationships in primary care are characterized by greater continuity and depth than in non-primary care specialties. We hypothesized that relationship styles of medical students based on ...