Browsing Psychiatry and Behavioral Sciences Publications by Title
Now showing items 1-20 of 38
-
Acute Modulation of Aged Human Memory by Pharmacological Manipulation of Glucocorticoids
(The Endocrine Society, 2002)In a previous longitudinal study of basal cortisol levels and cognitive function in humans, we showed that elderly humans with 4- to 7-yr cumulative exposure to high levels of cortisol present memory impairments, compared ... -
Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia
(Brain Res, 2008-02-15)The posterior paraventricular nucleus of the thalamus (THPVP) has been identified as a forebrain region that modulates the central nervous system (CNS) response to recurrent experiences of stressors. The THPVP is activated ... -
Adrenocortical responsiveness to adrenocorticotropin: StAR is ascendant.
(Endocrinology, 2009-06) -
Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder
(Frontiers in Behavioral Neuroscience, 2009-10-30)Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to ... -
Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer’s Disease
(JOURNAL OF ALZHEIMER'S DISEASE, 2010)Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise ... -
Alcohol Use Disorder as a Moderator in the Relationship Between PTSD and Suicidality Among Military Personnel
(2023-11-09)Background: Alcohol use disorder (AUD), posttraumatic stress disorder (PTSD), and suicide are substantial public health concerns among military service members, yet the nature of their relationships is not well understood. ... -
Antecedent Hindbrain Glucoprivation Does Not Impair the Counterregulatory Response to Hypoglycemia
(Diabetes, 2007-01)Recurrent hypoglycemia impairs hormonal counterregulatory responses (CRRs) to further bouts of hypoglycemia. The hypothalamus and hindbrain are both critical for sensing hypoglycemia and triggering CRRs. Hypothalamic ... -
Cardiovascular and Neuroendocrine Responses to Extended Laboratory Challenge
(American Psychosomatic Society, 1993)The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both ... -
Childhood Parental Loss and Adult Hypothalamic-Pituitary- Adrenal Function
(Biol. Psychiatry, 2008-06-15)Background—Several decades of research link childhood parental loss with risk for major depression and other forms of psychopathology. A large body of preclinical work on maternal separation and some recent studies of ... -
Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during ‘‘abstinence’’
(Alcohol, 2006-04)We have reported that repetitive daily ethanol consumption increased anxiety-like behavior in rats 4 weeks after ethanol consumption had ceased, consistent with the persistently increased anxiety exhibited by abstinent ... -
Chronic pain self-management for older adults: a randomized controlled trial [ISRCTN11899548]
(2004)Background: Chronic pain is a common and frequently disabling problem in older adults. Clinical guidelines emphasize the need to use multimodal therapies to manage persistent pain in this population. Pain self-management ... -
Circadian Clocks: Showtime for the Adrenal Cortex
(The Endocrine Society, 2008) -
Cortisol and ACTH Responses to the Dex/CRH Test: Influence of Temperament
(Horm. Behav., 2008-04)Temperament and personality traits such as neuroticism and behavioral inhibition are prospective predictors of the onset of depression and anxiety disorders. Exposure to stress is also linked to the development of these ... -
Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat
(Endocrinology, 2000)Pineal melatonin secretion declines with aging, whereas visceral fat, plasma insulin, and plasma leptin tend to increase. We have previously demonstrated that daily melatonin administration at middle age suppressed male ... -
Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
(Biol. Psychiatry, 2007-11-15)Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ... -
A descriptive study of older adults with persistent pain: Use and perceived effectiveness of pain management strategies [ISRCTN11899548]
(2005)Background: Persistent pain is a common, often debilitating, problem in older adults; however, few studies have focused on the experiences of older adults in managing their pain. The objective of this study was to describe ... -
Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo
(Environmental Health Perspectives, 2008-07-07)BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel ... -
DOPA Decarboxylase Modulates Tau Toxicity
(Elsevier, 2018-03-01)BACKGROUND: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple ... -
Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates
(Journal of Neuroscience, 1999-03-15)Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ...