Browsing Psychiatry and Behavioral Sciences Publications by Title
Now showing items 14-33 of 38
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Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat
(Endocrinology, 2000)Pineal melatonin secretion declines with aging, whereas visceral fat, plasma insulin, and plasma leptin tend to increase. We have previously demonstrated that daily melatonin administration at middle age suppressed male ... -
Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
(Biol. Psychiatry, 2007-11-15)Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ... -
A descriptive study of older adults with persistent pain: Use and perceived effectiveness of pain management strategies [ISRCTN11899548]
(2005)Background: Persistent pain is a common, often debilitating, problem in older adults; however, few studies have focused on the experiences of older adults in managing their pain. The objective of this study was to describe ... -
Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo
(Environmental Health Perspectives, 2008-07-07)BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel ... -
DOPA Decarboxylase Modulates Tau Toxicity
(Elsevier, 2018-03-01)BACKGROUND: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple ... -
Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates
(Journal of Neuroscience, 1999-03-15)Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ... -
Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
(Archives of Neurology, 2010-01)Objectives—To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor ... -
Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose
(Arch.Gen.Psychiatry, 1999-12)Background: Increasing plasma glucose levels improves memory in patients with Alzheimer disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, raising the question of whether memory ... -
Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues
(Investigative Ophthalmology & Visual Science,, 2001-07)PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ... -
High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury
(Frontiers in Neurology, 2012-02-07)Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ... -
Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study
(The Journal of Clinical Endocrinology & Metabolism, 2001)We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ... -
Hypopituitarism caused by blast-related mTBI may result in PTSD-like symptoms
(Society for Behavioral Neuroendocrinology, 2017-06-11)Recent studies in civilian populations have found the prevalence of hypopituitarism as a result of head injuries from all causes to be between 25 and 50%. However, the neuroendocrine effects of concussion, or mild traumatic ... -
Hypothalamic Melanin-Concentrating Hormone and Estrogen- Induced Weight Loss
(Journal of Neuroscience, 2000-11-15)Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ... -
Low Plasma Leptin Levels Contribute to Diabetic Hyperphagia in Rats
(Diabetes, 1999-06)The adipocyte hormone leptin reduces food intake in normal animals. During uncontrolled type 1 diabetes, plasma leptin levels fall, whereas food intake increases. To test the hypothesis that low leptin levels contribute ... -
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat
(American Psychological Society, 1999)Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ... -
parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism
(2005)Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to lateonset disease. This dosage pattern suggests ... -
Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis
(Am J Physiol Endocrinol Metab, 2004-08)Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab 287: E1107–E1113, 2004. First published August 10, 2004; ... -
Prediction of chronic disability in work-related musculoskeletal disorders: a prospective, population-based study
(2004)Background: Disability associated with work-related musculoskeletal disorders is an increasingly serious societal problem. Although most injured workers return quickly to work, a substantial number do not. The costs of ... -
Protocol Design for Utilizing Daily Assessments to Examine Daily Level Predictors of Impaired Driving Behaviors in Young Adults
(2021-11-17)Background: Motor vehicle crashes remain a leading cause of death among young adults (ages 18–25) in the United States. Many drivers implicated in these crashes are under the influence of alcohol, cannabis, or the simultaneous ...