Browsing Psychiatry and Behavioral Sciences Publications by Title
Now showing items 23-38 of 38
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Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues
(Investigative Ophthalmology & Visual Science,, 2001-07)PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ... -
High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury
(Frontiers in Neurology, 2012-02-07)Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ... -
Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study
(The Journal of Clinical Endocrinology & Metabolism, 2001)We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ... -
Hypopituitarism caused by blast-related mTBI may result in PTSD-like symptoms
(Society for Behavioral Neuroendocrinology, 2017-06-11)Recent studies in civilian populations have found the prevalence of hypopituitarism as a result of head injuries from all causes to be between 25 and 50%. However, the neuroendocrine effects of concussion, or mild traumatic ... -
Hypothalamic Melanin-Concentrating Hormone and Estrogen- Induced Weight Loss
(Journal of Neuroscience, 2000-11-15)Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ... -
Low Plasma Leptin Levels Contribute to Diabetic Hyperphagia in Rats
(Diabetes, 1999-06)The adipocyte hormone leptin reduces food intake in normal animals. During uncontrolled type 1 diabetes, plasma leptin levels fall, whereas food intake increases. To test the hypothesis that low leptin levels contribute ... -
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat
(American Psychological Society, 1999)Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ... -
parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism
(2005)Background: parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to lateonset disease. This dosage pattern suggests ... -
Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis
(Am J Physiol Endocrinol Metab, 2004-08)Physiological regulation of hypothalamic IL-1 gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab 287: E1107–E1113, 2004. First published August 10, 2004; ... -
Prediction of chronic disability in work-related musculoskeletal disorders: a prospective, population-based study
(2004)Background: Disability associated with work-related musculoskeletal disorders is an increasingly serious societal problem. Although most injured workers return quickly to work, a substantial number do not. The costs of ... -
Protocol Design for Utilizing Daily Assessments to Examine Daily Level Predictors of Impaired Driving Behaviors in Young Adults
(2021-11-17)Background: Motor vehicle crashes remain a leading cause of death among young adults (ages 18–25) in the United States. Many drivers implicated in these crashes are under the influence of alcohol, cannabis, or the simultaneous ... -
Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin
(American Journal of Physiology, 2008-08-27)A limiting factor to the clinical management of diabetes is iatrogenic hypoglycemia. With multiple hypoglycemic episodes, the collective neuroendocrine response that restores euglycemia is impaired. In our animal model ... -
Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet- Induced Obesity in Rats
(Endocrinology, 2005-12)Leptin gains access to the central nervous system where it influences activity of neuronal networks involved in ingestive behavior, neuroendocrine activity, and metabolism. In particular, the brain melanocortin (MC) ... -
The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia
(Am J Physiol Endocrinol Metab., 2008-05)Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate ... -
Ultra-brief intervention for problem drinkers: research protocol
(2008)Background: Helping the large number of problem drinkers who will never seek treatment is a challenging issue. Public health initiatives employing educational materials or mass media campaigns have met with mixed success. ... -
Using relationship styles based on attachment theory to improve understanding of specialty choice in medicine
(2006)Background: Patient-provider relationships in primary care are characterized by greater continuity and depth than in non-primary care specialties. We hypothesized that relationship styles of medical students based on ...