Now showing items 1-20 of 21

    • Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia 

      Al-Noori, Salwa; Sanders, Nicole M.; Wilkinson, Charles W.; Figlewicz, Dianne P.; Taborsky Jr., Gerald J. (Brain Res, 2008-02-15)
      The posterior paraventricular nucleus of the thalamus (THPVP) has been identified as a forebrain region that modulates the central nervous system (CNS) response to recurrent experiences of stressors. The THPVP is activated ...
    • Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder 

      Radant, Allen D.; Dobie, Dorcas J.; Peskind, Elaine R.; Murburg, M. Michele; Petrie, Eric C.; Kanter, Evan D.; Raskind, Murray A.; Wilkinson, Charles W. (Frontiers in Behavioral Neuroscience, 2009-10-30)
      Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to ...
    • Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer’s Disease 

      Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; McTiernan, Anne; Cholerton, Brenna A.; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (JOURNAL OF ALZHEIMER'S DISEASE, 2010)
      Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise ...
    • Antecedent Hindbrain Glucoprivation Does Not Impair the Counterregulatory Response to Hypoglycemia 

      Sanders, Nicole M.; Taborsky Jr., Gerald J; Wilkinson, Charles W.; Daumen, Wendi; Figlewicz, Dianne P. (Diabetes, 2007-01)
      Recurrent hypoglycemia impairs hormonal counterregulatory responses (CRRs) to further bouts of hypoglycemia. The hypothalamus and hindbrain are both critical for sensing hypoglycemia and triggering CRRs. Hypothalamic ...
    • Cardiovascular and Neuroendocrine Responses to Extended Laboratory Challenge 

      McCann, Barbara S.; Carter, James; Vaughan, Mary; Raskind, Murray; Wilkinson, Charles W.; Veith, Richard C. (American Psychosomatic Society, 1993)
      The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both ...
    • Childhood Parental Loss and Adult Hypothalamic-Pituitary- Adrenal Function 

      Tyrka, Audrey R.; Wier, Lauren; Price, Lawrence H; Ross, Nicole; Anderson, George M.; Wilkinson, Charles W.; Carpenter, Linda L. (Biol. Psychiatry, 2008-06-15)
      Background—Several decades of research link childhood parental loss with risk for major depression and other forms of psychopathology. A large body of preclinical work on maternal separation and some recent studies of ...
    • Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during ‘‘abstinence’’ 

      Rasmussen, Dennis D.; Wilkinson, Charles W.; Raskind, Murray A. (Alcohol, 2006-04)
      We have reported that repetitive daily ethanol consumption increased anxiety-like behavior in rats 4 weeks after ethanol consumption had ceased, consistent with the persistently increased anxiety exhibited by abstinent ...
    • Circadian Clocks: Showtime for the Adrenal Cortex 

      Wilkinson, Charles W. (The Endocrine Society, 2008)
    • Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment 

      Carpenter, Linda L.; Carvalho, John P.; Tyrka, Audrey R.; Wier, Lauren M.; Mello, Andrea F.; Anderson, George M.; Wilkinson, Charles W.; Price, Lawrence H. (Biol. Psychiatry, 2007-11-15)
      Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ...
    • Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo 

      Peretz, Alon; Sullivan, Jeffrey H.; Leotta, Daniel F.; Trenga, Carol A.; Sands, Fiona F.; Allen, Jason; Carlsten, Chris; Wilkinson, Charles W.; Gill, Edward A.; Kaufman, Joel D. (Environmental Health Perspectives, 2008-07-07)
      BACKGROUND: Traffic-related air pollution is consistently associated with cardiovascular morbidity and mortality. Recent human and animal studies suggest that exposure to air pollutants affects vascular function. Diesel ...
    • Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates 

      Leverenz, James P.; Wilkinson, Charles W.; Wamble, Molly; Corbin, Shannon; Grabber, Jo Ellen; Raskind, Murray A.; Raskind, Elaine R. (Journal of Neuroscience, 1999-03-15)
      Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ...
    • Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial 

      Baker, Laura D.; Frank, Laura L.; Foster-Schubert, Karen; Green, Pattie S.; Wilkinson, Charles W.; Mctiernan, Anne; Plymate, Stephen R.; Fishel, Mark A.; Watson, G. Stennis; Cholerton, Brenna A.; Duncan, Glen E.; Mehta, Pankaj D.; Craft, Suzanne (Archives of Neurology, 2010-01)
      Objectives—To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor ...
    • Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose 

      Crtaft, Suzanne; Asthana, Sanjay; Newcomer, John W.; Wilkinson, Charles W.; Tio Matos, Iris; Baker, Laura D.; Cherrier, Monique; Lofgreen, Cassin; Latendresse, Shawn; Petrova, Andreana; Plymate, Stephen; Raskind, Murray; Grimwood, Karla; Veith, Richard C. (Arch.Gen.Psychiatry, 1999-12)
      Background: Increasing plasma glucose levels improves memory in patients with Alzheimer disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, raising the question of whether memory ...
    • Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues 

      Clark, Abbot F.; Steely, Thomas; Dickerson Jr., Jaime E.; English-Wright, Sherry; Stropki, Karen; McCartney, Mitchell D.; Jaconson, Nasreen; Shepard, Allan R.; Clark, John I.; Matsushima, Hiroyuki; Peskind, Elaine R.; Leverenz, James B.; Wilkinson, Charles W.; Swiderski, Ruth E.; Fingert, John H.; Sheffield, Val C.; Stone, Edwin M. (Investigative Ophthalmology & Visual Science,, 2001-07)
      PURPOSE. To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids. METHODS. Myocilin expression was examined ...
    • High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury 

      Wilkinson, Charles W.; Pagulayan, Kathleen F.; Petrie, Eric C.; Mayer, Cynthia L.; Colasurdo, Elizabeth A.; Shofer, Jane B.; Hart, Kim L.; Hoff, David; Tarabochia, Matthew A.; Peskind, Elaine R. (Frontiers in Neurology, 2012-02-07)
      Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% ofcases. Most ...
    • Human Glucocorticoid Feedback Inhibition Is Reduced in Older Individuals: Evening Study 

      Wilkinson, Charles W.; Petrie, Eric C.; Murray, Sharon R.; Colasudro, Elizabeth A.; Raskind, Murray R.; Peskind, Elaine R. (The Journal of Clinical Endocrinology & Metabolism, 2001)
      We have previously shown that when tested in the morning, older men and women, pretreated with metyrapone to block endogenous cortisol synthesis, exhibit delayed suppression of plasma ACTH in response to cortisol infusion. ...
    • Hypothalamic Melanin-Concentrating Hormone and Estrogen- Induced Weight Loss 

      Mystkowski, Paul; Seely, Randy J.; Hahn, Tina M.; Baskin, Denis G.; Havel, Peter J.; Matsumoto, Alvin M.; Wilkinson, Charles W.; Peacock-Kinzig, Kimberly; Blake, Kathleen A.; Schwartz, Michael W. (Journal of Neuroscience, 2000-11-15)
      Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that ...
    • Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat 

      Van Dijk, Gertjan; Seely, Randy J.; Thiele, Todd E.; Friedman, Mark I.; Ji, Hong; Wilkinson, Charles W.; Burn, Paul; Campfield, Arthur; Tenenbauim, Renata; Raskin, Denis G.; Woods, Stephen C. (American Psychological Society, 1999)
      Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1425–R1433, 1999.—To investigate whether brain leptin ...
    • Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin 

      Al-Noori, Salwa; Sanders, Nicole M.; Taborsky, Gerald J.; Wilkinson, Charles W.; Zavosh, Aryana; West, Connie; Sanders, Colleen M.; Figlewicz, Dianne P. (American Journal of Physiology, 2008-08-27)
      A limiting factor to the clinical management of diabetes is iatrogenic hypoglycemia. With multiple hypoglycemic episodes, the collective neuroendocrine response that restores euglycemia is impaired. In our animal model ...
    • Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet- Induced Obesity in Rats 

      van Dijk, Gertjan; de Vries, Koert; Nyakas, Csaba; Buwalde, Bauke; Adage, Tiziana; Kuipers, Folkert; Kas, Martien J.H.; Adan, Roger A.H.; Wilkinson, Charles W.; Thiele, Todd E.; Scheurink, Anton J.W. (Endocrinology, 2005-12)
      Leptin gains access to the central nervous system where it influences activity of neuronal networks involved in ingestive behavior, neuroendocrine activity, and metabolism. In particular, the brain melanocortin (MC) ...