Now showing items 1-5 of 5

    • Cardiovascular and Neuroendocrine Responses to Extended Laboratory Challenge 

      McCann, Barbara S.; Carter, James; Vaughan, Mary; Raskind, Murray; Wilkinson, Charles W.; Veith, Richard C. (American Psychosomatic Society, 1993)
      The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both ...
    • Childhood Parental Loss and Adult Hypothalamic-Pituitary- Adrenal Function 

      Tyrka, Audrey R.; Wier, Lauren; Price, Lawrence H; Ross, Nicole; Anderson, George M.; Wilkinson, Charles W.; Carpenter, Linda L. (Biol. Psychiatry, 2008-06-15)
      Background—Several decades of research link childhood parental loss with risk for major depression and other forms of psychopathology. A large body of preclinical work on maternal separation and some recent studies of ...
    • Cortisol and ACTH Responses to the Dex/CRH Test: Influence of Temperament 

      Tyrka, Audrey M.; Wier, Lauren M.; Price, Lawrence H.; Rikhye, Kobita; Ross, Nicole S.; Anderson, George M.; Carpenter, Linda L.; Wilkinson, Charles M. (Horm. Behav., 2008-04)
      Temperament and personality traits such as neuroticism and behavioral inhibition are prospective predictors of the onset of depression and anxiety disorders. Exposure to stress is also linked to the development of these ...
    • Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment 

      Carpenter, Linda L.; Carvalho, John P.; Tyrka, Audrey R.; Wier, Lauren M.; Mello, Andrea F.; Anderson, George M.; Wilkinson, Charles W.; Price, Lawrence H. (Biol. Psychiatry, 2007-11-15)
      Background—Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. ...
    • Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates 

      Leverenz, James P.; Wilkinson, Charles W.; Wamble, Molly; Corbin, Shannon; Grabber, Jo Ellen; Raskind, Murray A.; Raskind, Elaine R. (Journal of Neuroscience, 1999-03-15)
      Chronic exposure to increased glucocorticoid concentrations appears to lower the threshold for hippocampal neuronal degeneration in the old rat. It has been proposed that increased brain exposure to glucocorticoids may ...