Browsing Faculty and Researcher Data and Papers by Subject "Rats"
Now showing items 1-20 of 32
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Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism
(Endocrine Society, 2003-11)The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to ... -
Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin
(Endocrine Society, 2003-04)Galanin and its newly discovered relative galanin-like peptide (GALP) are neuropeptides that are implicated in the neuroendocrine regulation of body weight and reproduction. GALP has been shown to bind in ... -
Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat
(Endocrine Society, 1983-03)Aging in the male rat is associated with a reduction in circulating testosterone levels. One possible cause of this decline is an age-related alteration of central nervous system-mediated LH secretion. To ... -
Effect of CGS 20267 on ovarian aromatase and gonadotropin levels in the rat
(Springer Verlag, 1998-03)Aromatase catalyzes the rate limiting step that converts androgens to estrogens. Postmenopausal women with hormone dependent breast cancer respond to first generation aromatase inhibitors such as aminoglutethimide ... -
Evidence for activation of the central nervous system-pituitary mechanism for gonadotropin secretion at the time of puberty in the male rat
(Endocrine Society, 1986-07)During sexual development in the male rat, serum testosterone (T) levels increase markedly at 45-60 days of age. At the time of the pubertal rise in T levels, activation of the hypothalamic-pituitary axis is ... -
Expression and sexual dimorphism of galanin messenger ribonucleic acid in growth hormone-releasing hormone neurons of the rat during development
(Endocrine Society, 1994-02)In the rat, the secretion of GH is episodic and sexually dimorphic. The development and regulation of this patterning of GH secretion are governed by the reciprocal influence of the hypothalamic peptide ... -
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
(Endocrine Society, 2000-07)Galanin-like peptide (GALP), which was recently isolated from the porcine hypothalamus, shares sequence homology with galanin and binds with high affinity to galanin receptors. To study the distribution and ... -
Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat
(Endocrine Society, 1990-08)Testicular function is regulated by the negative feedback effect of sex hormones acting at the brain and pituitary to inhibit the secretion of LH and FSH. An important component of this feedback axis is ... -
Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons
(Endocrine Society, 1992-08)The activity of both somatostatin (SS) and GH-releasing hormone (GHRH) neurons within several hypothalamic nuclei is regulated, in part, by the feedback effects of GH. However, whether GH, or its intermediate, ... -
Growth hormone-releasing hormone messenger ribonucleic acid in the hypothalamus of the adult male rat is increased by testosterone
(Endocrine Society, 1990-09)Since intact adult male rats have higher GH pulse amplitude than do castrated animals and since GH-releasing hormone (GHRH) secretion is predominantly responsible for the production of these GH pulses, we ... -
Hormonal regulation of spermatogenesis
(Blackwell Publishing, 2004-12)Proper functioning of the mammalian testis is dependent upon an array of hormonal messengers acting through endocrine, paracrine, and autocrine pathways. Within the testis, the primary messengers are the ... -
Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens
(Endocrine Society, 1994-09)Androgens are essential for the maintenance of normal spermatogenesis in the rat. We assessed the sites, developmental pattern, and hormonal control of androgen receptors (AR) in the rat testis. Adult male ... -
Induction of galanin gene expression in gonadotropin-releasing hormone neurons with puberty in the rat
(Endocrine Society, 1994-10)The onset of puberty reflects the developmental activation of GnRH neurons whose secretory activity awakens the reproductive axis; however, the cellular mechanisms involved in this activational process remain ... -
Inhibition of steroid-induced galanin mRNA expression in GnRH neurons by specific NMDA-receptor blockade
(Blackwell Publishing, 1996-03)Galanin mRNA levels in GnRH neurons increase in association with a steroid-induced LH surge in female rats. Both the steroid-induced LH surge and the concomitant increase of galanin mRNA in GnRH neurons are ... -
Leptin is a metabolic gate for the onset of puberty in the female rat
(Endocrine Society, 1997-02)The timing of puberty onset in mammals is tightly coupled to the animal's nutritional and metabolic state. We conducted two experiments to test the hypothesis that leptin acts as a metabolic signal for the ... -
Mechanisms involved in the homologous down-regulation of transcription of the follicle-stimulating hormone receptor gene in Sertoli cells
(Elsevier, 2001-02-28)The action of follicle-stimulating hormone (FSH) in spermatogenesis is regulated at a fundamental level by controlling the number of competent receptors present at the surface of Sertoli cells. By controlling ... -
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
(Endocrine Society, 1997-10)Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic ... -
Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat
(Endocrine Society, 1989-04)Pubertal development in mammals is in part attributable to a brain-dependent process, whereby increased pulsatile GnRH secretion leads to the awakening of the entire reproductive system. However, the brain ... -
Regulation of galanin and gonadotropin-releasing hormone gene expression in the hypothalamus and basal forebrain of the rat
(Elsevier, 1994-12)Galanin is a cotransmitter in GnRH neurons and is thought to play a role in the control of gonadotropin secretion. The aim of our research has been to learn how galanin mRNA is regulated in GnRH neurons with ... -
Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat
(Endocrine Society, 1993-04)Galanin is colocalized with GnRH in neurons of the hypothalamus and basal forebrain of female rats, and this neuropeptide may play a role in the generation of the midcycle surge of gonadotropin secretion. We ...