Browsing Faculty and Researcher Data and Papers by Subject "galanin"
Now showing items 1-14 of 14
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Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat [see comments]
(Endocrine Society, 1994-05)In rats, galanin is colocalized in GnRH neurons, and galanin mRNA in GnRH neurons is increased coincidentally with the preovulatory gonadotropin surge. Whether the induction of galanin mRNA in GnRH neurons ... -
Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin
(Endocrine Society, 2003-04)Galanin and its newly discovered relative galanin-like peptide (GALP) are neuropeptides that are implicated in the neuroendocrine regulation of body weight and reproduction. GALP has been shown to bind in ... -
Distribution and regulation of galanin receptor 1 messenger RNA in the forebrain of wild type and galanin-transgenic mice
(Endocrine Society, 2003)To learn more about molecular alterations in the brain that occur as a consequence of either the chronic excess or absence of peptide neurotransmitters, we examined the impact of genetically manipulating the ... -
Galanin overexpressing transgenic mice
(Elsevier, 2002-04)Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as ... -
Induction of galanin gene expression in gonadotropin-releasing hormone neurons with puberty in the rat
(Endocrine Society, 1994-10)The onset of puberty reflects the developmental activation of GnRH neurons whose secretory activity awakens the reproductive axis; however, the cellular mechanisms involved in this activational process remain ... -
Inhibition of steroid-induced galanin mRNA expression in GnRH neurons by specific NMDA-receptor blockade
(Blackwell Publishing, 1996-03)Galanin mRNA levels in GnRH neurons increase in association with a steroid-induced LH surge in female rats. Both the steroid-induced LH surge and the concomitant increase of galanin mRNA in GnRH neurons are ... -
Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin
(American Society for Microbiology, 2004-04)Neuropeptide Y (NPY) and galanin have both been implicated in the regulation of body weight, yet mice bearing deletions of either of these molecules have unremarkable metabolic phenotypes. To investigate ... -
Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)
(American Society for Microbiology, 2005-06)Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and ... -
Regulation of galanin and gonadotropin-releasing hormone gene expression in the hypothalamus and basal forebrain of the rat
(Elsevier, 1994-12)Galanin is a cotransmitter in GnRH neurons and is thought to play a role in the control of gonadotropin secretion. The aim of our research has been to learn how galanin mRNA is regulated in GnRH neurons with ... -
Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat
(Endocrine Society, 1993-04)Galanin is colocalized with GnRH in neurons of the hypothalamus and basal forebrain of female rats, and this neuropeptide may play a role in the generation of the midcycle surge of gonadotropin secretion. We ... -
Regulation of gonadotropin-releasing hormone (GnRH) and galanin gene expression in GnRH neurons during lactation in the rat [published erratum appears in Endocrinology 1994 Jan;134(1):498]
(Endocrine Society, 1993-09)Galanin is colocalized with GnRH, and its expression in these neurons is enhanced at proestrus, a time of activation of GnRH neurons. We tested the hypothesis that the expression of both the GnRH and galanin ... -
The role of galanin and its receptor in the feedback regulation of growth hormone secretion
(Endocrine Society, 1996-12)GH controls its own secretion through a mechanism involving short-loop feedback regulation of the synthesis and release of GH-releasing hormone (GHRH). GHRH neurons coexpress the peptide galanin, but the ... -
Sexual differentiation of galanin gene expression in gonadotropin-releasing hormone neurons
(Endocrine Society, 1996-11)In adult rats, only females are capable of generating an LH surge in response to high levels of ovarian steroids. This is because the ability to generate LH surges in adulthood in response to ovarian steroids ... -
Stimulation of sexual behavior in the male rat by galanin-like peptide
(Elsevier, 2004-12)Galanin-like peptide (GALP) is a recently described neuropeptide, which shares a partial sequence identity with galanin but is derived from a separate gene. Central injections of GALP stimulate the secretion ...